Product Name
GLRA1, Blocking Peptide
Full Product Name
GLRA1 Peptide
Product Gene Name
GLRA1 blocking peptide
[Similar Products]
Product Synonym Gene Name
STHE[Similar Products]
GLRA1 peptide (MBS3225153) is used for blocking the activity of GLRA1 antibody (MBS3224466)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P23415
Form/Format
Lyophilized powder
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of GLRA1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
GLRA1 blocking peptide
This is a synthetic peptide designed for use in combination with anti-GLRA1 antibody made
Target Description: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
Product Categories/Family for GLRA1 blocking peptide
Peptide
Applications Tested/Suitable for GLRA1 blocking peptide
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for GLRA1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000162
[Other Products]
NCBI GenBank Nucleotide #
NM_000171
[Other Products]
UniProt Primary Accession #
P23415
[Other Products]
UniProt Related Accession #
P23415[Other Products]
NCBI Official Full Name
glycine receptor subunit alpha-1 isoform 2
NCBI Official Synonym Full Names
glycine receptor alpha 1
NCBI Official Symbol
GLRA1??[Similar Products]
NCBI Official Synonym Symbols
STHE; HKPX1
??[Similar Products]
NCBI Protein Information
glycine receptor subunit alpha-1
UniProt Protein Name
Glycine receptor subunit alpha-1
UniProt Synonym Protein Names
Glycine receptor 48 kDa subunit; Glycine receptor strychnine-binding subunit
Protein Family
Glycine receptor
UniProt Gene Name
GLRA1??[Similar Products]
UniProt Entry Name
GLRA1_HUMAN
NCBI Summary for GLRA1
The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Multiple transcript variants encoding different isoforms have been found. [provided by RefSeq, Dec 2015]
UniProt Comments for GLRA1
GLRA1: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing). Defects in GLRA1 are the cause of hyperekplexia, hereditary, type 1 (HKPX1). A neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub- subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, ion channel; Transporter
Chromosomal Location of Human Ortholog: 5q32
Cellular Component: postsynaptic membrane; intracellular membrane-bound organelle; integral to plasma membrane; integral to membrane; plasma membrane; cell junction; external side of plasma membrane
Molecular Function: protein binding; transmitter-gated ion channel activity; extracellular-glycine-gated chloride channel activity; glycine binding; taurine binding
Biological Process: regulation of action potential; startle response; synaptic transmission, glycinergic; righting reflex; acrosome reaction; chloride transport; neurological control of breathing; ***** walking behavior; regulation of inhibitory postsynaptic membrane potential; neuromuscular process controlling posture; regulation of membrane potential; visual perception; negative regulation of transmission of nerve impulse; muscle contraction; neuropeptide signaling pathway; ion transport; transmembrane transport
Disease: Hyperekplexia, Hereditary 1
Research Articles on GLRA1
1. Results support the notion that the efficacies of ligands for the alpha1 GlyR are determined by conformational changes that occur within and near the ligand-binding domain: disruption of the D97-R119 interaction may be an important element in receptor activation and that agonists may break this putative intersubunit bond in order to destabilize the initial shut state and facilitate transitions towards the open state.
Precautions
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