Product Name
Galpha olf, Polyclonal Antibody
Popular Item
Full Product Name
Galpha olf Polyclonal Antibody
Product Synonym Names
Ga olf Polyclonal Antibody; GNAL; Guanine nucleotide-binding protein G(olf) subunit alpha; Adenylate cyclase-stimulating G alpha protein; olfactory type
Product Gene Name
anti-Galpha olf antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P38405
Species Reactivity
Human, Mouse, Rat
Specificity
Ga olf Polyclonal Antibody detects endogenous levels of Ga olf protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration
1 mg/ml (lot specific)
Immunogen Description
Synthesized peptide derived from the Internal region of human Ga olf.
Preparation and Storage
Store at -20 degree C/1 year
Other Notes
Small volumes of anti-Galpha olf antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-Galpha olf antibody
Total protein Ab
Applications Tested/Suitable for anti-Galpha olf antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-Galpha olf antibody
Western Blot: 1:500 - 1:2000
Immunohistochemistry: 1:100 - 1:300
ELISA: 1:20000
Not yet tested in other applications.
Western Blot (WB) of anti-Galpha olf antibody
Western Blot analysis of HEPG2-UV cells using Ga olf Polyclonal Antibody
Western Blot (WB) of anti-Galpha olf antibody
Western Blot analysis of HepG2-UV cells using Ga olf Polyclonal Antibody
NCBI/Uniprot data below describe general gene information for Galpha olf. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001135811.1
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NCBI GenBank Nucleotide #
NM_001142339.2
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UniProt Primary Accession #
P38405
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UniProt Secondary Accession #
Q86XU3; B7ZA26[Other Products]
UniProt Related Accession #
P38405[Other Products]
Molecular Weight
SDS-PAGE: 40kd
NCBI Official Full Name
guanine nucleotide-binding protein G(olf) subunit alpha isoform 2
NCBI Official Synonym Full Names
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
NCBI Official Symbol
GNAL??[Similar Products]
NCBI Official Synonym Symbols
DYT25
??[Similar Products]
NCBI Protein Information
guanine nucleotide-binding protein G(olf) subunit alpha
UniProt Protein Name
Guanine nucleotide-binding protein G(olf) subunit alpha
UniProt Synonym Protein Names
Adenylate cyclase-stimulating G alpha protein, olfactory type
UniProt Gene Name
GNAL??[Similar Products]
UniProt Entry Name
GNAL_HUMAN
NCBI Summary for Galpha olf
This gene encodes a stimulatory G protein alpha subunit which mediates odorant signaling in the olfactory epithelium. This protein couples dopamine type 1 receptors and adenosine A2A receptors and is widely expressed in the central nervous system. Mutations in this gene have been associated with dystonia 25 and this gene is located in a susceptibility region for bipolar disorder and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
UniProt Comments for Galpha olf
G-alpha(olf): Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters. Belongs to the G-alpha family. G(s) subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: G protein, heterotrimeric; Membrane protein, peripheral; G protein, heterotrimeric alpha G(s)
Chromosomal Location of Human Ortholog: 18p11.22-p11.21
Cellular Component: plasma membrane; heterotrimeric G-protein complex
Molecular Function: GTPase activity; signal transducer activity; GTP binding; G-protein-coupled receptor binding; metal ion binding; G-protein beta/gamma-subunit binding
Biological Process: synaptic transmission; metabolic process; sensory perception of smell; adenylate cyclase activation; response to amphetamine; G-protein signaling, adenylate cyclase inhibiting pathway; signal transduction; G-protein signaling, adenylate cyclase activating pathway; dopamine receptor, adenylate cyclase activating pathway; response to caffeine
Disease: Dystonia 25
Research Articles on Galpha olf
1. The findings of this study further support GNAL as causative gene in *****-onset isolated dystonia.
Precautions
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Disclaimer
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