Full Product Name
Anti-EYA4 Antibody
Product Gene Name
anti-EYA4 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse
Purity/Purification
Affinity Purified
Concentration
100ug/200ul (lot specific)
Immunogen
EDSQDLNEQSVKKTC
Storage Buffer
Supplied at 0.5 mg/ml in Tris saline,0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Other Notes
Small volumes of anti-EYA4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-EYA4 antibody
Western Blot (WB), ELISA (EIA)
NCBI/Uniprot data below describe general gene information for EYA4. It may not necessarily be applicable to this product.
NCBI Accession #
CAA76636.1
[Other Products]
UniProt Secondary Accession #
O95464; O95679; Q8IW39; Q9NTR7; B7Z7F7[Other Products]
UniProt Related Accession #
O95677[Other Products]
Molecular Weight
63,911 Da
NCBI Official Full Name
EYA4 protein
NCBI Official Synonym Full Names
EYA transcriptional coactivator and phosphatase 4
NCBI Official Symbol
EYA4??[Similar Products]
NCBI Official Synonym Symbols
CMD1J; DFNA10
??[Similar Products]
NCBI Protein Information
eyes absent homolog 4
UniProt Protein Name
Eyes absent homolog 4
Protein Family
Eyes absent
UniProt Gene Name
EYA4??[Similar Products]
NCBI Summary for EYA4
This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant non-syndromic sensorineural 10 locus. The encoded protein is also a putative oncogene that mediates DNA repair, apoptosis, and innate immunity following DNA damage, cellular damage, and viral attack. Defects in this gene are also associated with dilated cardiomyopathy 1J. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
UniProt Comments for EYA4
EYA4: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye. Defects in EYA4 are the cause of deafness autosomal dominant type 10 (DFNA10). DFNA10 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Defects in EYA4 are the cause of cardiomyopathy dilated type 1J (CMD1J). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Belongs to the HAD-like hydrolase superfamily. EYA family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 6q23.2
Cellular Component: nucleus
Molecular Function: protein binding; protein tyrosine phosphatase activity
Biological Process: anatomical structure morphogenesis; cell differentiation; histone dephosphorylation; positive regulation of DNA repair; visual perception
Disease: Cardiomyopathy, Dilated, 1j; Deafness, Autosomal Dominant 10
Research Articles on EYA4
1. The identification of a novel EYA4 truncation mutation associated with DFNA10, rather than syndromic hearing loss, supports a previously reported genotype-phenotype correlation in this gene.
Precautions
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