Product Name
Lipoproteins (VLDLR), Protein
Full Product Name
Lipoproteins; Very Low Density; Human Plasma; Suitable for Cell Culture
Product Synonym Names
VLDL
Product Gene Name
VLDLR protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P98155
Host
Human Plasma
Source: Human
Purity/Purification
>= 95%
Form/Format
Liquid
In 150 mM NaCl; pH 7.4; 0.01% EDTA
Preparation and Storage
Store at 2-6 degree C for 6 months.
Centrifuge the vial prior to opening.
Other Notes
Small volumes of VLDLR protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
VLDLR protein
In a normal fasting individual; VLDL concentrations range from 0.5- 2.0 g/L. VLDL transports triglycerides synthesized by the liver to sites of energy storage and utilization.
Applications Tested/Suitable for VLDLR protein
SDS-PAGE
NCBI/Uniprot data below describe general gene information for VLDLR. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001018066.1
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NCBI GenBank Nucleotide #
NM_001018056.2
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UniProt Primary Accession #
P98155
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UniProt Secondary Accession #
Q5VVF6; B2RMZ7; D3DRH6[Other Products]
UniProt Related Accession #
P98155[Other Products]
Molecular Weight
0.01-80; 000 kDa
NCBI Official Full Name
very low-density lipoprotein receptor isoform b
NCBI Official Synonym Full Names
very low density lipoprotein receptor
NCBI Official Symbol
VLDLR??[Similar Products]
NCBI Official Synonym Symbols
CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH
??[Similar Products]
NCBI Protein Information
very low-density lipoprotein receptor
UniProt Protein Name
Very low-density lipoprotein receptor
Protein Family
Very low-density lipoprotein receptor
UniProt Gene Name
VLDLR??[Similar Products]
UniProt Synonym Gene Names
VLDL receptor; VLDL-R??[Similar Products]
NCBI Summary for VLDLR
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009]
UniProt Comments for VLDLR
VLDLR: Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation. Defects in VLDLR are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 1 (CMARQ1); also known as dysequilibrium syndrome (DES) or non- progressive cerebellar disorder with mental retardation. CMARQ1 is a congenital, non-progressive cerebellar ataxia associated with disturbed equilibrium, delayed ambulation, mental retardation and cerebellar hypoplasia. Additional features include short stature, strabismus, pes planus and, rarely, seizures. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 9p24.2
Cellular Component: lysosomal membrane; membrane; plasma membrane; receptor complex
Molecular Function: apolipoprotein binding; calcium-dependent protein binding; glycoprotein binding; low-density lipoprotein receptor activity; protein binding; very-low-density lipoprotein binding; very-low-density lipoprotein receptor activity
Biological Process: axon guidance; low-density lipoprotein receptor catabolic process; memory; negative regulation of transcription from RNA polymerase II promoter; nervous system development; receptor-mediated endocytosis; signal transduction
Disease: Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 1
Research Articles on VLDLR
1. We screened for mutations in RELN or VLDLR and compared the phenotype of these patients with that of previously reported patients. differences in clinical severity, involvement of the cerebellar hemispheres, together with the severity of the neocortical defect, enables RELN-mutated patients to be distinguished from VLDLR-mutated patients.
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