Full Product Name
CARM1 Polyclonal Antibody
Product Synonym Names
Coactivator associated arginine methyltransferase 1
Product Gene Name
anti-CARM1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P98155
Species Reactivity
Human, Mouse
Purity/Purification
Affinity Purified
Form/Format
Colorless liquid
100 ml affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol; 0.5% BSA; and 0.01% thimerosal.
Concentration
0.5 mg/ml (lot specific)
Immunogen
Synthetic peptide of human CARM1.
Preparation and Storage
Store at -20 degree C for 12 months.
The antibody solution should be gently mixed before use.
Other Notes
Small volumes of anti-CARM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CARM1 antibody
Polyclonal Antibody to detect CARM1 in Human; Mouse samples.
Product Categories/Family for anti-CARM1 antibody
CARM1
Applications Tested/Suitable for anti-CARM1 antibody
Western Blot (WB)
Application Notes for anti-CARM1 antibody
Western Blot: 1-4 ug
NCBI/Uniprot data below describe general gene information for CARM1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001018066.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001018056.2
[Other Products]
UniProt Primary Accession #
P98155
[Other Products]
UniProt Secondary Accession #
Q5VVF6; B2RMZ7; D3DRH6[Other Products]
UniProt Related Accession #
P98155[Other Products]
Molecular Weight
93,383 Da
NCBI Official Full Name
very low-density lipoprotein receptor isoform b
NCBI Official Synonym Full Names
very low density lipoprotein receptor
NCBI Official Symbol
VLDLR??[Similar Products]
NCBI Official Synonym Symbols
CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH
??[Similar Products]
NCBI Protein Information
very low-density lipoprotein receptor
UniProt Protein Name
Very low-density lipoprotein receptor
Protein Family
Histone-arginine methyltransferase
UniProt Gene Name
VLDLR??[Similar Products]
UniProt Synonym Gene Names
VLDL receptor; VLDL-R??[Similar Products]
NCBI Summary for CARM1
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009]
UniProt Comments for CARM1
VLDLR: Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation. Defects in VLDLR are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 1 (CMARQ1); also known as dysequilibrium syndrome (DES) or non- progressive cerebellar disorder with mental retardation. CMARQ1 is a congenital, non-progressive cerebellar ataxia associated with disturbed equilibrium, delayed ambulation, mental retardation and cerebellar hypoplasia. Additional features include short stature, strabismus, pes planus and, rarely, seizures. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 9p24.2
Cellular Component: lysosomal membrane; membrane; plasma membrane; receptor complex
Molecular Function: apolipoprotein binding; calcium-dependent protein binding; glycoprotein binding; low-density lipoprotein receptor activity; protein binding; very-low-density lipoprotein binding; very-low-density lipoprotein receptor activity
Biological Process: axon guidance; low-density lipoprotein receptor catabolic process; memory; negative regulation of transcription from RNA polymerase II promoter; nervous system development; receptor-mediated endocytosis; signal transduction
Disease: Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 1
Research Articles on CARM1
1. We screened for mutations in RELN or VLDLR and compared the phenotype of these patients with that of previously reported patients. differences in clinical severity, involvement of the cerebellar hemispheres, together with the severity of the neocortical defect, enables RELN-mutated patients to be distinguished from VLDLR-mutated patients.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
