ATP2C2; SPCA2; KIAA0703; SPCA2; Calcium-transporting ATPase type 2C member 2; ATPase 2C2; ATPase, Ca++ transporting, type 2C, member 2

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

At least three isoforms of ATP2C2 are known to exist. ATP2C2 antibody will not cross-react with ATP2C1

ATP2C2 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL (lot specific)

ATP2C2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Small volumes of anti-ATP2C2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

ATP2C2 Antibody: ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles. Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation. Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

ATP2C2 antibody can be used for detection of ATP2C2 by Western blot at 1 mug/mL. Antibody can also be used for immunofluorescence starting at 20 mug/mL. For immunofluorescence start at 20 mug/mL.

Western blot analysis of ATP2C2 in 3T3 cell lysate with ATP2C2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.

Immunofluorescence of ATP2C2 in 3T3 cells with ATP2C2 antibody at 20 μg/mL.

106,235 Da

ATPase, Ca++ transporting, type 2C, member 2

calcium-transporting ATPase type 2C member 2; ATPase 2C2; secretory pathway Ca(2+)-ATPase 2; secretory pathway calcium ATPase 2

Calcium-transporting ATPase type 2C member 2

KIAA0703; SPCA2; ATPase 2C2??[Similar Products]

AT2C2_HUMAN

ATP2C2: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.3.8; Membrane protein, integral; Hydrolase; Transporter; Transporter, ion channel; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 16q24.1

Cellular Component: Golgi membrane; integral to membrane

Molecular Function: protein binding; calcium-transporting ATPase activity; metal ion binding; ATP binding

Biological Process: metabolic process; transmembrane transport

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