Activin-A Mouse; Activin-A Mouse Recombinant; Inhba; Inhibin beta A; FSH releasing protein

For Research Use Only. Not for use in diagnostic procedures.

E Coli

Greater than 95% as obsereved by SDS-PAGE.

Mouse Activin-A was lyophilized from a concentrated 1mg/ml protein solution containing 0.02% TFA
Lyophilized freeze dried powder.

Lyophilized Activin-A although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Activin-A should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Small volumes of mActivin A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Description: Active form Activin-A Murine Recombinant produced in E Coli is a homodimeric, non-glycosylated, polypeptide chain containing 2 x 117 amino acids and having a molecular weight of 26.2kDa.The Active form Activin-A is purified by standard chromatographic techniques.

Introduction: Activins are homodimers or heterodimers of the different beta subunit isoforms, part of the TGFbeta family. Mature Activin A has two 116 amino acids residues betaA subunits (betaA-betaA). Activin displays an extensive variety of biological activities, including mesoderm induction, neural cell differentiation, bone remodelling, haematopoiesis, and reproductive physiology. Activins takes part in the production and regulation of hormones such as FSH, LH, GnRH and ACTH. Cells that are identified to express Activin A include fibroblasts, endothelial cells, hepatocytes, vascular smooth muscle cells, macrophages, keratinocytes, osteoclasts, bone marrow monocytes, prostatic epithelium, neurons, chondrocytes, osteoblasts, Leydig cells, Sertoli cells, and ovarian granulosa cells.

CYTOKINES AND GROWTH FACTORS; Growth Factors; Activin

47,392 Da

inhibin beta-A

inhibin beta A chain; activin beta-A chain

Inhibin beta A chain

INHBA_MOUSE

INHBA: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted

Cellular Component: extracellular space; cell; extracellular region

Molecular Function: identical protein binding; growth factor activity; protein heterodimerization activity; hormone activity; peptide hormone binding; cytokine activity; transforming growth factor beta receptor binding; receptor binding

Biological Process: positive regulation of transcription, DNA-dependent; positive regulation of cellular protein metabolic process; activin receptor signaling pathway; mesodermal cell differentiation; palate development; negative regulation of cell cycle; odontogenesis; regulation of apoptosis; negative regulation of cell proliferation; hair follicle development; ovarian follicle development; cell cycle arrest; response to drug; hemoglobin biosynthetic process; regulation of follicle-stimulating hormone secretion; positive regulation of erythrocyte differentiation; male gonad development; negative regulation of hair follicle development; progesterone secretion; regulation of transcription from RNA polymerase II promoter; mesoderm formation; regulation of MAPKKK cascade; positive regulation of transcription from RNA polymerase II promoter; hemopoietic progenitor cell differentiation; negative regulation of cell growth; cell development; G1/S transition of mitotic cell cycle; growth

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