Full Product Name
MATR3 Polyclonal Antibody
Product Synonym Names
Matrin-3; MATR3; KIAA0723
Product Gene Name
anti-MATR3 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P43243
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-MATR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-MATR3 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-MATR3 antibody
WB: 1:500-2000
ELISA: 1:5000-20000
NCBI/Uniprot data below describe general gene information for MATR3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001181883.1
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NCBI GenBank Nucleotide #
NM_001194954.1
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UniProt Primary Accession #
P43243
[Other Products]
UniProt Secondary Accession #
Q9UHW0; Q9UQ27; B7ZAV5; D3DQC3[Other Products]
UniProt Related Accession #
P43243[Other Products]
NCBI Official Full Name
matrin-3 isoform a
NCBI Official Synonym Full Names
matrin 3
NCBI Official Symbol
MATR3??[Similar Products]
NCBI Official Synonym Symbols
MPD2; ALS21; VCPDM
??[Similar Products]
NCBI Protein Information
matrin-3
UniProt Protein Name
Matrin-3
UniProt Gene Name
MATR3??[Similar Products]
UniProt Synonym Gene Names
KIAA0723??[Similar Products]
NCBI Summary for MATR3
This gene encodes a nuclear matrix protein, which is proposed to stabilize certain messenger RNA species. Mutations of this gene are associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts composed of the upstream small nucleolar RNA host gene 4 (non-protein coding) and matrin 3 gene sequence, have been identified. Pseudogenes of this gene are located on chromosomes 1 and X. [provided by RefSeq, Aug 2013]
UniProt Comments for MATR3
May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). May bind to specific miRNA hairpins (PubMed:28431233).
Research Articles on MATR3
1. Depletion of SAFB1 reduced FUS's localization to chromatin-bound fraction and splicing activity, suggesting SAFB1 could tether FUS to chromatin compartment thorough N-terminal DNA-binding motif. Moreover, FUS interacts with another nuclear matrix-associated protein, Matrin3.
Precautions
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Disclaimer
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