Matrin-3; MATR3; KIAA0723

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This MATR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 157-186 amino acids from the N-terminal region of human MATR3.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.3 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-MATR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This locus encodes a nuclear matrix protein. Mutations at
this locus have been associated with distal myopathy 2, which often
includes vocal cord and pharyngeal weakness. Alternatively spliced
transcript variants, including read-through transcripts with an
upstream locus have been described. Related pseuodgenses have been
defined on chr1 and chrX.

Western Blot (WB), ELISA (EIA)

WB~~1:1000

MATR3 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the MATR3 antibody detected the MATR3 protein (arrow).

94623

matrin 3

matrin-3

Matrin-3

KIAA0723??[Similar Products]

MATR3_HUMAN

This gene encodes a nuclear matrix protein, which is proposed to stabilize certain messenger RNA species. Mutations of this gene are associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts composed of the upstream small nucleolar RNA host gene 4 (non-protein coding) and matrin 3 gene sequence, have been identified. Pseudogenes of this gene are located on chromosomes 1 and X. [provided by RefSeq, Aug 2013]

matrin 3: an acidic protein that is a component of the nuclear matrix. May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network.

Protein type: RNA processing; RNA-binding

Chromosomal Location of Human Ortholog: 5q31.2

Cellular Component: nucleoplasm; nuclear matrix; membrane; nuclear inner membrane

Molecular Function: protein binding; zinc ion binding; nucleotide binding; structural molecule activity

Disease: Amyotrophic Lateral Sclerosis 21

Zeitz, M.J., et al. J. Cell. Biochem. 108(1):125-133(2009)
Senderek, J., et al. Am. J. Hum. Genet. 84(4):511-518(2009)
Graubert, T.A., et al. PLoS ONE 4 (2), E4583 (2009) :
Malyavantham, K.S., et al. J. Cell. Biochem. 105(2):391-403(2008)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)

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