Full Product Name
LDL Receptor antibody
Product Synonym Names
Monoclonal LDL Receptor; Anti-LDL Receptor; LDL Receptor; Low Density Lipoprotein Receptor; Anti LDL Receptor
Product Gene Name
anti-LDL antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for A2ARV4
Species Reactivity
Bovine, Human
Specificity
Bovine adrenal cortex LDL receptor
Purity/Purification
Affinity purified
Form/Format
Lyophilized. Reconstitute in 1 ml dist. water (final solution contains 0.5% BSA in PBS buffer, pH 7.4)
Biological Significance
Low-density lipoprotein (LDL) is one of the five major groups of lipoproteins, which in order of size, largest to smallest, are chylomicrons, VLDL, IDL, LDL and HDL, that enable lipids like cholesterol and triglycerides to be transported within the water-based bloodstream. Blood tests typically report LDL-C, the amount of cholesterol contained in LDL. In clinical context, mathematically calculated estimates of LDL-C are commonly used to estimate how much low density lipoproteins are driving progression of atherosclerosis. Direct LDL measurements are also available.
Immunogen
LDL receptor antibody was raised in mouse using purified bovine adreanal cortex LDL receptor as the immunogen.
Preparation and Storage
Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze-thaw cycles.
Other Notes
Small volumes of anti-LDL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LDL antibody
Mouse monoclonal LDL Receptor antibody
Product Categories/Family for anti-LDL antibody
Cardiac Markers
Applications Tested/Suitable for anti-LDL antibody
Immunofluorescence (IF)
Application Notes for anti-LDL antibody
IF: 1:10-1:50
NCBI/Uniprot data below describe general gene information for LDL. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001074557.1
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NCBI GenBank Nucleotide #
NM_001081088.1
[Other Products]
UniProt Primary Accession #
A2ARV4
[Other Products]
UniProt Secondary Accession #
P70215; Q3TL35; Q9JLB3[Other Products]
UniProt Related Accession #
A2ARV4[Other Products]
Molecular Weight
519,208 Da
NCBI Official Full Name
low-density lipoprotein receptor-related protein 2
NCBI Official Synonym Full Names
low density lipoprotein receptor-related protein 2
NCBI Official Symbol
Lrp2??[Similar Products]
NCBI Official Synonym Symbols
Gp330; Megalin; AI315343; AW536255; b2b1625.2Clo; D230004K18Rik
??[Similar Products]
NCBI Protein Information
low-density lipoprotein receptor-related protein 2
UniProt Protein Name
Low-density lipoprotein receptor-related protein 2
UniProt Synonym Protein Names
Glycoprotein 330; gp330; Megalin
Protein Family
LDLR chaperone
UniProt Gene Name
Lrp2??[Similar Products]
UniProt Synonym Gene Names
LRP-2; gp330??[Similar Products]
UniProt Entry Name
LRP2_MOUSE
UniProt Comments for LDL
LRP2: Acts together with cubilin to mediate HDL endocytosis. May participate in regulation of parathyroid- hormone and para-thyroid-hormone-related protein release. Defects in LRP2 are the cause of Donnai-Barrow syndrome (DBS); also known as faciooculoacousticorenal syndrome (FOAR syndrome). DBS is a rare autosomal recessive disorder characterized by major malformations including agenesis of the corpus callosum, congenital diaphragmatic hernia, facial dysmorphology, ocular anomalies, sensorineural hearing loss and developmental delay. The FOAR syndrome was first described as comprising facial anomalies, ocular anomalies, sensorineural hearing loss, and proteinuria. DBS and FOAR were first described as distinct disorders but the classic distinguishing features between the 2 disorders were presence of proteinuria and absence of diaphragmatic hernia and corpus callosum anomalies in FOAR. Early reports noted that the 2 disorders shared many phenotypic features and may be identical. Although there is variability in the expression of some features (e.g. agenesis of the corpus callosum and proteinuria), DBS and FOAR are now considered to represent the same entity. Belongs to the LDLR family.
Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Membrane protein, integral
Cellular Component: Golgi apparatus; extracellular space; protein complex; brush border membrane; endoplasmic reticulum; lysosomal membrane; integral to membrane; coated pit; lipid raft; membrane; endocytic vesicle; apical part of cell; cytoplasm; apical plasma membrane; endosome; receptor complex; brush border
Molecular Function: protein binding; lipoprotein transporter activity; hemoglobin binding; low-density lipoprotein receptor binding; metal ion binding; protein complex binding; calcium ion binding; receptor activity; SH3 domain binding; PDZ domain binding
Biological Process: hormone secretion; cell proliferation; receptor-mediated endocytosis; vitamin metabolic process; lipoprotein transport; forebrain development; hemoglobin import; endocytosis; transcytosis; endosome transport; response to X-ray
Research Articles on LDL
1. megalin-deficient mice may provide a valuable model for future studies of megalin in ocular physiology and pathology.
Precautions
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Disclaimer
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