Product Name
TBX22, Blocking Peptide
Full Product Name
TBX22 Blocking Peptide
Product Synonym Names
TBOX22; T-box transcription factor TBX22; T-box protein 22
Product Gene Name
TBX22 blocking peptide
[Similar Products]
TBX22 peptide (MBS8205971) is used for blocking the activity of TBX22 antibody (MBS827243)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9Y458
Form/Format
Lyophilized powder
Quality Control
The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
Directions for Use
Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Other Notes
Small volumes of TBX22 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
TBX22 blocking peptide
The peptide is used to block Anti-TBX22 Antibody reactivity.
Applications Tested/Suitable for TBX22 blocking peptide
Blocking (BL)
NCBI/Uniprot data below describe general gene information for TBX22. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001103348.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001109878.1
[Other Products]
UniProt Primary Accession #
Q9Y458
[Other Products]
UniProt Secondary Accession #
Q5JZ06; Q96LC0; Q9HBF1[Other Products]
UniProt Related Accession #
Q9Y458[Other Products]
Molecular Weight
44,718 Da
NCBI Official Full Name
T-box transcription factor TBX22 isoform 1
NCBI Official Synonym Full Names
T-box 22
NCBI Official Symbol
TBX22??[Similar Products]
NCBI Official Synonym Symbols
CPX; CLPA; TBXX; ABERS; dJ795G23.1
??[Similar Products]
NCBI Protein Information
T-box transcription factor TBX22
UniProt Protein Name
T-box transcription factor TBX22
Protein Family
T-box transcription factor
UniProt Gene Name
TBX22??[Similar Products]
UniProt Synonym Gene Names
TBOX22; T-box protein 22??[Similar Products]
UniProt Entry Name
TBX22_HUMAN
NCBI Summary for TBX22
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene have been associated with the inherited X-linked disorder, Cleft palate with ankyloglossia, and it is believed to play a major role in human palatogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for TBX22
TBX22: Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis. Defects in TBX22 are the cause of X-linked cleft palate with ankyloglossia (CPX). 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: Xq21.1
Cellular Component: nucleus
Molecular Function: DNA binding; transcription factor activity
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
Disease: Cleft Palate With Or Without Ankyloglossia, X-linked; Abruzzo-erickson Syndrome
Research Articles on TBX22
1. These results suggest that a loss-of-function mutation in the X-linked TBX22 promoter may cause the cleft palate through disruption of TBX22-ETS-1 pathway.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
