MPD2; ALS21; VCPDM

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

The antibody detects endogenous levels of total MATR3 protein.

Antigen affinity purification.

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

2.3 mg/ml (lot specific)

Store at -20 degree C

Small volumes of anti-MATR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a nuclear matrix protein, which is proposed to stabilize certain messenger RNA species. Mutations of this gene are associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts composed of the upstream small nucleolar RNA host gene 4 (non-protein coding) and matrin 3 gene sequence, have been identified. Pseudogenes of this gene are located on chromosomes 1 and X.

Total protein Ab

Western Blot (WB)

Western blotting: 1:500-1:2000

Gel: 6%SDS-PAGE Lysates (from left to right): 293T, K562, hela, 231, Jurkat and NIH/3T3 cell Amount of lysate: 40ug per lane Primary antibody: 1/500 dilution Secondary antibody dilution: 1/8000 Exposure time: 3 seconds

62,576 Da

matrin 3

matrin-3

Matrin-3

KIAA0723??[Similar Products]

MATR3_HUMAN

This gene encodes a nuclear matrix protein, which is proposed to stabilize certain messenger RNA species. Mutations of this gene are associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts composed of the upstream small nucleolar RNA host gene 4 (non-protein coding) and matrin 3 gene sequence, have been identified. Pseudogenes of this gene are located on chromosomes 1 and X. [provided by RefSeq, Aug 2013]

matrin 3: an acidic protein that is a component of the nuclear matrix. May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network.

Protein type: RNA processing; RNA-binding

Chromosomal Location of Human Ortholog: 5q31.2

Cellular Component: nucleoplasm; nuclear matrix; membrane; nuclear inner membrane

Molecular Function: protein binding; zinc ion binding; nucleotide binding; structural molecule activity

Disease: Amyotrophic Lateral Sclerosis 21

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