Full Product Name
TBX22 Rabbit Polyclonal
Product Gene Name
anti-TBX22 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-TBX22 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-TBX22 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for TBX22. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001103349.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001109879.1
[Other Products]
UniProt Secondary Accession #
Q5JZ06; Q96LC0; Q9HBF1[Other Products]
UniProt Related Accession #
Q9Y458[Other Products]
Molecular Weight
44,718 Da
NCBI Official Full Name
T-box transcription factor TBX22 isoform 2
NCBI Official Synonym Full Names
T-box 22
NCBI Official Symbol
TBX22??[Similar Products]
NCBI Official Synonym Symbols
CPX; CLPA; TBXX; ABERS; dJ795G23.1
??[Similar Products]
NCBI Protein Information
T-box transcription factor TBX22
UniProt Protein Name
T-box transcription factor TBX22
Protein Family
T-box transcription factor
UniProt Gene Name
TBX22??[Similar Products]
UniProt Synonym Gene Names
TBOX22; T-box protein 22??[Similar Products]
UniProt Entry Name
TBX22_HUMAN
NCBI Summary for TBX22
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene have been associated with the inherited X-linked disorder, Cleft palate with ankyloglossia, and it is believed to play a major role in human palatogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for TBX22
TBX22: Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis. Defects in TBX22 are the cause of X-linked cleft palate with ankyloglossia (CPX). 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: Xq21.1
Cellular Component: nucleus
Molecular Function: DNA binding; protein binding; transcription factor activity
Biological Process: multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; transcription, DNA-dependent
Disease: Abruzzo-erickson Syndrome; Cleft Palate With Or Without Ankyloglossia, X-linked
Research Articles on TBX22
1. These results suggest that a loss-of-function mutation in the X-linked TBX22 promoter may cause the cleft palate through disruption of TBX22-ETS-1 pathway.
Precautions
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Disclaimer
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