Full Product Name
TBX22 Antibody
Product Synonym Names
CPX; CLPA; TBXX; dJ795G23.1
Product Gene Name
anti-TBX22 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9Y458
Specificity
The antibody detects endogenous levels of total TBX22 protein.
Purity/Purification
Antigen affinity purification.
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Concentration
0.4 mg/ml (lot specific)
Immunogen Type
Recombinant Protein
Immunogen Description
Fusion protein corresponding to residues near the C terminal of human T-box 22
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-TBX22 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TBX22 antibody
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene have been associated with the inherited X-linked disorder, Cleft palate with ankyloglossia, and it is believed to play a major role in human palatogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Product Categories/Family for anti-TBX22 antibody
Total protein Ab
Applications Tested/Suitable for anti-TBX22 antibody
Immunohistochemistry (IHC)
Application Notes for anti-TBX22 antibody
Immunohistochemistry: 1:25-1:100
Immunohistochemistry (IHC) of anti-TBX22 antibody
Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue using at dilution 1/15.
NCBI/Uniprot data below describe general gene information for TBX22. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001103348.1
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NCBI GenBank Nucleotide #
NM_001109878.1
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UniProt Primary Accession #
Q9Y458
[Other Products]
UniProt Secondary Accession #
Q5JZ06; Q96LC0; Q9HBF1[Other Products]
UniProt Related Accession #
Q9Y458[Other Products]
Molecular Weight
44,718 Da
NCBI Official Full Name
T-box transcription factor TBX22 isoform 1
NCBI Official Synonym Full Names
T-box 22
NCBI Official Symbol
TBX22??[Similar Products]
NCBI Official Synonym Symbols
CPX; CLPA; TBXX; ABERS; dJ795G23.1
??[Similar Products]
NCBI Protein Information
T-box transcription factor TBX22
UniProt Protein Name
T-box transcription factor TBX22
Protein Family
T-box transcription factor
UniProt Gene Name
TBX22??[Similar Products]
UniProt Synonym Gene Names
TBOX22; T-box protein 22??[Similar Products]
UniProt Entry Name
TBX22_HUMAN
NCBI Summary for TBX22
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene have been associated with the inherited X-linked disorder, Cleft palate with ankyloglossia, and it is believed to play a major role in human palatogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for TBX22
TBX22: Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis. Defects in TBX22 are the cause of X-linked cleft palate with ankyloglossia (CPX). 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: Xq21.1
Cellular Component: nucleus
Molecular Function: DNA binding; transcription factor activity
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
Disease: Cleft Palate With Or Without Ankyloglossia, X-linked; Abruzzo-erickson Syndrome
Research Articles on TBX22
1. These results suggest that a loss-of-function mutation in the X-linked TBX22 promoter may cause the cleft palate through disruption of TBX22-ETS-1 pathway.
Precautions
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Disclaimer
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