Rat Rab3 GTPase-activating protein non-catalytic subunit (RAB3GAP2) ELISA kit; RP11-568G11.1; DKFZp434D245; FLJ14579; KIAA0839; RAB3-GAP150; RAB3GAP150; p150; rab3 GTPase-activating protein 150 kDa subunit; rab3 GTPase-activating protein non-catalytic subunit; rab3 GTPase-activa; RAB3 GTPase activating protein subunit 2 (non-catalytic)

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of RAB3GAP2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9330285 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the RAB3 GTPase activating protein subunit 2 (non-catalytic) (RAB3GAP2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing RAB3GAP2. The ELISA analytical biochemical technique of the MBS9330285 kit is based on RAB3GAP2 antibody-RAB3GAP2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect RAB3GAP2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, RAB3GAP2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

154,431 Da

RAB3 GTPase activating protein subunit 2

rab3 GTPase-activating protein non-catalytic subunit; RAB3-GAP150; rab3-GAP p150; rab3-GAP regulatory subunit; rab3 GTPase-activating protein 150 kDa subunit

Rab3 GTPase-activating protein non-catalytic subunit

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RBGPR_RAT

RAB3GAP2: Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3- GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non- synaptic vesicular release of neurotransmitters. Defects in RAB3GAP2 are the cause of Martsolf syndrome (MARTS). Martsolf syndrome is characterized by congenital cataracts, mental retardation, and hypogonadism. Inheritance is autosomal recessive. Defects in RAB3GAP2 are the cause of Warburg micro syndrome type 2 (WARBM2). WARBM2 is a rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism. Belongs to the Rab3-GAP regulatory subunit family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs, Rab; GAPs

Cellular Component: protein complex; cytoplasm; plasma membrane

Molecular Function: protein heterodimerization activity; Rab guanyl-nucleotide exchange factor activity; Rab GTPase binding; GTPase activator activity; enzyme regulator activity

Biological Process: regulation of GTPase activity; positive regulation of GTPase activity

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