Product Name
LDLRAP1, Polyclonal Antibody
Full Product Name
LDLRAP1 Antibody
Product Synonym Names
ARH; ARH1; ARH2; DKFZp586D0624; FHCB1; FHCB2; MGC34705
Product Gene Name
anti-LDLRAP1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Immunogen
Fusion protein of LDLRAP1
Calculated Molecular Weight: 308aa; 34kd
Observed Molecular Weight: 34kd
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-26734 / sc-130692 / sc-292294
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-LDLRAP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-LDLRAP1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-LDLRAP1 antibody
WB: 1:500-1:5000
Testing Data of anti-LDLRAP1 antibody
NCBI/Uniprot data below describe general gene information for LDLRAP1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_056442.2
[Other Products]
NCBI GenBank Nucleotide #
NM_015627.2
[Other Products]
UniProt Secondary Accession #
Q6TQS9; Q8N2Y0; Q9UFI9; A2BHI5[Other Products]
UniProt Related Accession #
Q5SW96[Other Products]
Molecular Weight
33,885 Da
NCBI Official Full Name
low density lipoprotein receptor adapter protein 1
NCBI Official Synonym Full Names
low density lipoprotein receptor adaptor protein 1
NCBI Official Symbol
LDLRAP1??[Similar Products]
NCBI Official Synonym Symbols
ARH; ARH1; ARH2; FHCB1; FHCB2
??[Similar Products]
NCBI Protein Information
low density lipoprotein receptor adapter protein 1; LDL receptor adaptor protein; autosomal recessive hypercholesterolemia protein
UniProt Protein Name
Low density lipoprotein receptor adapter protein 1
UniProt Synonym Protein Names
Autosomal recessive hypercholesterolemia protein
Protein Family
Low density lipoprotein receptor adapter protein
UniProt Gene Name
LDLRAP1??[Similar Products]
UniProt Synonym Gene Names
ARH??[Similar Products]
UniProt Entry Name
ARH_HUMAN
NCBI Summary for LDLRAP1
The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia. [provided by RefSeq, Jul 2008]
UniProt Comments for LDLRAP1
LDLRAP1: Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Defects in LDLRAP1 are the cause of autosomal recessive hypercholesterolemia (ARH). ARH is a disorder caused by defective internalization of LDL receptors (LDLR) in the liver. ARH has the clinical features of familial hypercholesterolemia (FH) homozygotes, including severely elevated plasma LDL cholesterol, tuberous and tendon xanthomata, and premature atherosclerosis. LDL receptor (LDLR) activity measured in skin fibroblasts is normal, as the LDL binding ability.
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component: recycling endosome; internal side of plasma membrane; AP-1 adaptor complex; axon; early endosome; neurofilament; basal plasma membrane; AP-2 adaptor complex; cytosol
Molecular Function: clathrin binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; receptor signaling complex scaffold activity; low-density lipoprotein receptor binding; phosphotyrosine binding; beta-amyloid binding
Biological Process: receptor-mediated endocytosis; cholesterol metabolic process; cholesterol homeostasis; positive regulation of signal transduction; transport; amyloid precursor protein metabolic process; regulation of protein binding; receptor internalization; positive regulation of receptor-mediated endocytosis
Disease: Hypercholesterolemia, Autosomal Recessive
Research Articles on LDLRAP1
1. Identification of ARH gene and characterization of its mutations in Autosomal Recessive Hypercholesterolemia patients [Review]
Precautions
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Disclaimer
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