Full Product Name
SBDS antibody
Product Synonym Names
SDS; SWDS; CGI-97
Product Gene Name
anti-SBDS antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9Y3A5
Species Reactivity
Human, Mouse, Rat
Specificity
The antibody detects endogenous level of total SBDS antibody.
Purity/Purification
Antibodies were purified by affinity purification using immunogen.
Form/Format
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (lot specific)
Immunogen Type
Recombinant Protein
Immunogen Description
Recombinant protein of human SBDS.
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-SBDS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SBDS antibody
This gene encodes a member of a highly conserved protein family that exists from archaea to vertebrates and plants. The encoded protein may function in RNA metabolism. Mutations within this gene are associated with Shwachman-Bodian-Diamond syndrome. An alternative transcript has been described, but its
biological nature has not been determined. This gene has a closely linked pseudogene that is distally located.
Product Categories/Family for anti-SBDS antibody
Total protein Ab
Applications Tested/Suitable for anti-SBDS antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-SBDS antibody
Western blotting: 1:500 - 1:2000
Immunofluorescence: 1:50 - 1:200
Western Blot (WB) of anti-SBDS antibody
Western blot analysis of extracts of various cell lines, using SBDS antibody.
Immunofluorescence (IF) of anti-SBDS antibody
Immunofluorescence analysis of MCF7 cell using SBDS antibody. Blue: DAPI for nuclear staining.
NCBI/Uniprot data below describe general gene information for SBDS. It may not necessarily be applicable to this product.
NCBI Accession #
NP_057122.2
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NCBI GenBank Nucleotide #
NM_016038.2
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UniProt Primary Accession #
Q9Y3A5
[Other Products]
UniProt Secondary Accession #
Q96FX0; Q9NV53; A8K0P4[Other Products]
UniProt Related Accession #
Q9Y3A5[Other Products]
Molecular Weight
28,764 Da
NCBI Official Full Name
ribosome maturation protein SBDS
NCBI Official Synonym Full Names
Shwachman-Bodian-Diamond syndrome
NCBI Official Symbol
SBDS??[Similar Products]
NCBI Official Synonym Symbols
SDS; SWDS; CGI-97
??[Similar Products]
NCBI Protein Information
ribosome maturation protein SBDS
UniProt Protein Name
Ribosome maturation protein SBDS
UniProt Synonym Protein Names
Shwachman-Bodian-Diamond syndrome protein
Protein Family
Ribosome maturation protein
UniProt Gene Name
SBDS??[Similar Products]
UniProt Entry Name
SBDS_HUMAN
NCBI Summary for SBDS
This gene encodes a member of a highly conserved protein family that exists from archaea to vertebrates and plants. The encoded protein may function in RNA metabolism. Mutations within this gene are associated with Shwachman-Bodian-Diamond syndrome. An alternative transcript has been described, but its biological nature has not been determined. This gene has a closely linked pseudogene that is distally located. [provided by RefSeq, Jul 2008]
UniProt Comments for SBDS
SBDS: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP- dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. Defects in SBDS are the cause of Shwachman-Diamond syndrome (SDS). SDS is an autosomal recessive disorder characterized by pancreatic exocrine insufficiency, hematologic dysfunction, and skeletal abnormalities. Belongs to the SDO1/SBDS family.
Protein type: Nucleolus
Chromosomal Location of Human Ortholog: 7q11.21
Cellular Component: nucleoplasm; spindle pole; cytoplasm; nucleolus; nucleus
Molecular Function: rRNA binding; protein binding; microtubule binding; ribosome binding
Biological Process: bone marrow development; cell proliferation; leukocyte chemotaxis; ribosomal large subunit biogenesis and assembly; mitotic spindle stabilization; inner cell mass cell proliferation; mature ribosome assembly; bone mineralization; rRNA processing
Disease: Shwachman-diamond Syndrome; Aplastic Anemia
Research Articles on SBDS
1. Genetic variations in exon 2 of SBDS gene do not appear to be contributing to aplastic anemia in the north Indian population.
Precautions
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