Full Product Name
Anti-SBDS Antibody
Product Gene Name
anti-SBDS antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Immunogen
Recombinant protein of human SBDS
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-SBDS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SBDS antibody
This gene encodes a member of a highly conserved protein family that exists from archaea to vertebrates and plants. The encoded protein may function in RNA metabolism. Mutations within this gene are associated with Shwachman-Bodian-Diamond syndrome.
Applications Tested/Suitable for anti-SBDS antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-SBDS antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
IF: 1:50-1:200
NCBI/Uniprot data below describe general gene information for SBDS. It may not necessarily be applicable to this product.
NCBI Accession #
AKI71780.1
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UniProt Secondary Accession #
Q96FX0; Q9NV53; A8K0P4[Other Products]
UniProt Related Accession #
Q9Y3A5[Other Products]
Molecular Weight
28,764 Da
NCBI Official Full Name
SBDS, partial
NCBI Official Synonym Full Names
SBDS, ribosome maturation factor
NCBI Official Symbol
SBDS??[Similar Products]
NCBI Official Synonym Symbols
SDS; SWDS; CGI-97
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NCBI Protein Information
ribosome maturation protein SBDS
UniProt Protein Name
Ribosome maturation protein SBDS
UniProt Synonym Protein Names
Shwachman-Bodian-Diamond syndrome protein
Protein Family
Ribosome maturation protein
UniProt Gene Name
SBDS??[Similar Products]
NCBI Summary for SBDS
This gene encodes a highly conserved protein that plays an essential role in ribosome biogenesis. The encoded protein interacts with elongation factor-like GTPase 1 to disassociate eukaryotic initiation factor 6 from the late cytoplasmic pre-60S ribosomal subunit allowing assembly of the 80S subunit. Mutations within this gene are associated with the autosomal recessive disorder Shwachman-Bodian-Diamond syndrome. This gene has a closely linked pseudogene that is distally located. [provided by RefSeq, Jan 2017]
UniProt Comments for SBDS
Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.
Research Articles on SBDS
1. Structural variation in SBDS gene, with loss of exon 3, in two Shwachman-Diamond patients.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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