Product Name
FGF23, Polyclonal Antibody
Popular Item
Full Product Name
FGF23 Antibody
Product Synonym Names
Fibroblast growth factor 23; FGF-23; Tumor-derived hypophosphatemia-inducing factor; HYPF
Product Gene Name
anti-FGF23 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9GZV9
Species Reactivity
Human, Mouse, Rat
Specificity
FGF23 Antibody detects endogenous levels of total FGF23 protein.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human FGF23.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-FGF23 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-FGF23 antibody
Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-FGF23 antibody
IF: 1:100~1:500
ELISA: 1:20000
Immunofluorescence (IF) of anti-FGF23 antibody
Immunofluorescence analysis of HUVEC cells, using FGF23 Antibody. The picture on the right is blocked with the synthesized peptide.
NCBI/Uniprot data below describe general gene information for FGF23. It may not necessarily be applicable to this product.
NCBI Accession #
NP_065689.1
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NCBI GenBank Nucleotide #
NM_020638.2
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UniProt Primary Accession #
Q9GZV9
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UniProt Secondary Accession #
Q4V758[Other Products]
UniProt Related Accession #
Q9GZV9[Other Products]
NCBI Official Full Name
fibroblast growth factor 23
NCBI Official Synonym Full Names
fibroblast growth factor 23
NCBI Official Symbol
FGF23??[Similar Products]
NCBI Official Synonym Symbols
ADHR; FGFN; HYPF; HPDR2; PHPTC
??[Similar Products]
NCBI Protein Information
fibroblast growth factor 23
UniProt Protein Name
Fibroblast growth factor 23
UniProt Synonym Protein Names
Phosphatonin; Tumor-derived hypophosphatemia-inducing factor
Protein Family
Fibroblast growth factor
UniProt Gene Name
FGF23??[Similar Products]
UniProt Synonym Gene Names
HYPF; FGF-23??[Similar Products]
NCBI Summary for FGF23
This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of
biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013]
UniProt Comments for FGF23
Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (). Acts directly on the parathyroid to decrease PTH secretion (). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.
Research Articles on FGF23
1. A statistically significant positive correlation was found between s-Klotho and FGF23 (r=0.768; p=0.001), and between FGF23 levels and urinary albumin creatinine ratio (r=0.768; p=0.001).
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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