Product Name
Glutaredoxin-related protein 5, mitochondrial (Glrx5), Recombinant Protein
Full Product Name
Recombinant Mouse Glutaredoxin-related protein 5, mitochondrial (Glrx5)
Product Gene Name
Glrx5 recombinant protein
[Similar Products]
Product Synonym Gene Name
Glrx5[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
32-152aa, Full Length of Mature Protein
Sequence
ASSGGQAEQL DALVKKDKVV VFLKGTPEQP QCGFSNAVVQ ILRLHGVRDY AAYNVLDDPE LRQGIKDYSN WPTIPQVYLN GEFVGGCDIL LQMHQNGDLV EELKKLGIRS ALVDEKDQDS K
3D Structure
ModBase 3D Structure for Q80Y14
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Glrx5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Glrx5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_082695.1
[Other Products]
NCBI GenBank Nucleotide #
NM_028419.3
[Other Products]
UniProt Primary Accession #
Q80Y14
[Other Products]
UniProt Secondary Accession #
Q3YML1; Q9D6E9[Other Products]
UniProt Related Accession #
Q80Y14[Other Products]
Molecular Weight
16,292 Da
NCBI Official Full Name
glutaredoxin-related protein 5, mitochondrial
NCBI Official Synonym Full Names
glutaredoxin 5
NCBI Official Symbol
Glrx5??[Similar Products]
NCBI Protein Information
glutaredoxin-related protein 5, mitochondrial
UniProt Protein Name
Glutaredoxin-related protein 5, mitochondrial
UniProt Synonym Protein Names
Monothiol glutaredoxin-5
Protein Family
Glutaredoxin-related protein
UniProt Gene Name
Glrx5??[Similar Products]
NCBI Summary for Glrx5
This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in the human gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, Sep 2015]
UniProt Comments for Glrx5
Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (). Involved in protein lipoylation, acting in the pathway that provides an iron-sulfur cluster to lipoate synthase (). Required for normal iron homeostasis (). Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (). May protect cells against apoptosis due to reactive oxygen species and oxidative stress (PubMed:19442627).
Research Articles on Glrx5
1. Study reports a decrease of Grx expression levels in pancreatic islets of diabetic mice which was accompanied by declining insulin secretion, increase of reactive oxygen species (ROS) production level, and cell cycle alterations. These data demonstrate the essential role of the Grx system for the beta-cell during metabolic stress which may provide a new target for diabetes mellitus type 2 treatment.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
