Full Product Name
GLRX5, CT (GLRX5, C14orf87, Glutaredoxin-related protein 5, mitochondrial, Monothiol glutaredoxin-5)
Product Synonym Names
Anti -GLRX5, CT (GLRX5, C14orf87, Glutaredoxin-related protein 5, mitochondrial, Monothiol glutaredoxin-5)
Product Gene Name
anti-GLRX5 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 14; NC_000014.8 (96001323..96011055). Location: 14q32.13
3D Structure
ModBase 3D Structure for Q86SX6
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Immunogen
GLRX5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-157 amino acids from the C-terminal region of human GLRX5.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-GLRX5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GLRX5 antibody
GLRX5 is monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. GLRX5 required for normal iron homeostasis. GLRX5 is required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1.
Product Categories/Family for anti-GLRX5 antibody
Antibodies; Abs to Mitochondrial Proteins
Applications Tested/Suitable for anti-GLRX5 antibody
ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes for anti-GLRX5 antibody
Suitable for use in Western Blot, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Flow Cytometry: 1:10-50
NCBI/Uniprot data below describe general gene information for GLRX5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_057501.2
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NCBI GenBank Nucleotide #
NM_016417.2
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UniProt Primary Accession #
Q86SX6
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UniProt Secondary Accession #
Q0X088; Q3YML0; Q86WY3; Q8IZ54[Other Products]
UniProt Related Accession #
Q86SX6[Other Products]
Molecular Weight
16,628 Da[Similar Products]
NCBI Official Full Name
glutaredoxin-related protein 5, mitochondrial
NCBI Official Synonym Full Names
glutaredoxin 5
NCBI Official Symbol
GLRX5??[Similar Products]
NCBI Official Synonym Symbols
GRX5; FLB4739; PR01238; PRO1238; C14orf87
??[Similar Products]
NCBI Protein Information
glutaredoxin-related protein 5, mitochondrial; glutaredoxin 5 homolog; monothiol glutaredoxin-5
UniProt Protein Name
Glutaredoxin-related protein 5, mitochondrial
UniProt Synonym Protein Names
Monothiol glutaredoxin-5
Protein Family
Glutaredoxin-related protein
UniProt Gene Name
GLRX5??[Similar Products]
UniProt Synonym Gene Names
C14orf87??[Similar Products]
UniProt Entry Name
GLRX5_HUMAN
NCBI Summary for GLRX5
This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia. [provided by RefSeq, May 2010]
UniProt Comments for GLRX5
GLRX5: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1. Defects in GLRX5 are a cause of anemia sideroblastic pyridoxine-refractory autosomal recessive (PRARSA). A form of sideroblastic anemia not responsive to pyridoxine. Sideroblastic anemia is characterized by anemia of varying severity, hypochromic peripheral erythrocytes, systemic iron overload secondary to chronic ineffective erythropoiesis, and the presence of bone marrow ringed sideroblasts. Sideroblasts are characterized by iron-loaded mitochondria clustered around the nucleus. Belongs to the glutaredoxin family. Monothiol subfamily.
Protein type: Oxidoreductase
Chromosomal Location of Human Ortholog: 14q32.13
Cellular Component: mitochondrion; nucleus
Molecular Function: 2 iron, 2 sulfur cluster binding; electron carrier activity; metal ion binding; protein disulfide oxidoreductase activity
Biological Process: cell redox homeostasis; hemopoiesis
Disease: Anemia, Sideroblastic, Pyridoxine-refractory, Autosomal Recessive
Research Articles on GLRX5
1. crystal structure of GLRX5 revealed a tetrameric organization with the [2Fe-2S] clusters buried in the interior and shielded from the solvent by the conserved beta1-alpha2 loop
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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