AGPAT7; AYTL3; LPEAT2 1-acylglycerol-3-phosphate O-acyltransferase 7

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

AGPAT7 Antibody detects endogenous levels of total AGPAT7

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1.0mg/mL (lot specific)

Store at -20 degree C

Small volumes of anti-AGPAT7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Total protein Ab

Western Blot (WB)

Western Blot: 1:1000-3000

Western blot analysis AGPAT7 using HT29 whole cell lysates

57,219 Da

lysophosphatidylcholine acyltransferase 4

lysophospholipid acyltransferase LPCAT4

Lysophospholipid acyltransferase LPCAT4

AGPAT7; AYTL3; LPEAT2; 1-AGP acyltransferase 7; 1-AGPAT 7??[Similar Products]

LPCT4_HUMAN

Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. Both LPA and PA are involved in signal transduction (Ye et al., 2005 [PubMed 16243729]).[supplied by OMIM, May 2008]

AGPAT7: Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1- alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl- phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

Protein type: EC 2.3.1.121; EC 2.3.1.23; EC 2.3.1.67; EC 2.3.1.n6; EC 2.3.1.n7; Membrane protein, integral; Membrane protein, multi-pass; Transferase

Chromosomal Location of Human Ortholog: 15q14

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; membrane

Molecular Function: 1-acylglycerol-3-phosphate O-acyltransferase activity; 2-acylglycerol-3-phosphate O-acyltransferase activity

Biological Process: phosphatidic acid biosynthetic process; phospholipid metabolic process; triacylglycerol biosynthetic process

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