Product Name
GCS1 (MOGS), Polyclonal Antibody
Full Product Name
GCS1 antibody - N-terminal region
Product Gene Name
anti-MOGS antibody
[Similar Products]
Product Synonym Gene Name
GCS1; CDG2B[Similar Products]
Antibody/Peptide Pairs
GCS1 peptide (MBS3233255) is used for blocking the activity of GCS1 antibody (MBS3208293)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: GPYGWEFHDG LSFGRQHIQD GALRLTTEFV KRPGGQHGGD WSWRVTVEPQ
3D Structure
ModBase 3D Structure for Q13724
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 85%
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human GCS1
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-MOGS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MOGS antibody
This is a rabbit polyclonal antibody against GCS1. It was validated on Western Blot using a cell lysate as a positive control.
Target Description: GCS1 is the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum.This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum.
Product Categories/Family for anti-MOGS antibody
Polyclonal; Membrane Protein; Drugs and Drug Metabolism; Glycosylation;
Applications Tested/Suitable for anti-MOGS antibody
Western Blot (WB)
Western Blot (WB) of anti-MOGS antibody
WB Suggested Anti-GCS1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Hela cell lysate
NCBI/Uniprot data below describe general gene information for MOGS. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006293
[Other Products]
NCBI GenBank Nucleotide #
NM_006302
[Other Products]
UniProt Primary Accession #
Q13724
[Other Products]
UniProt Related Accession #
Q13724[Other Products]
NCBI Official Full Name
mannosyl-oligosaccharide glucosidase isoform 1
NCBI Official Synonym Full Names
mannosyl-oligosaccharide glucosidase
NCBI Official Symbol
MOGS??[Similar Products]
NCBI Official Synonym Symbols
DER7; GCS1; CDG2B; CWH41
??[Similar Products]
NCBI Protein Information
mannosyl-oligosaccharide glucosidase
UniProt Protein Name
Mannosyl-oligosaccharide glucosidase
UniProt Synonym Protein Names
Processing A-glucosidase I
Protein Family
Mannosyl-oligosaccharide glucosidase
UniProt Gene Name
MOGS??[Similar Products]
UniProt Synonym Gene Names
GCS1??[Similar Products]
UniProt Entry Name
MOGS_HUMAN
NCBI Summary for MOGS
This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Research Articles on MOGS
1. A shortened immunoglobulin half-life was determined to be the mechanism underlying the hypogammaglobulinemia in congenital disorder of glycosylation type IIb (CDG-IIb).
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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