Product Name
Neurokinin B (TAC3), Peptide
Full Product Name
Neurokinin B (Biotin)
Product Gene Name
TAC3 peptide
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 12; NC_000012.11 (57403781..57410344, complement). Location: 12q13-q21
3D Structure
ModBase 3D Structure for Q9UHF0
Purity/Purification
Highly Purified
~95%. Purified by HPLC.
Form/Format
Supplied as a lyophilized powder.
Sequence (linear)
Biotin-Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of TAC3 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for TAC3 peptide
Molecular Biology; MB-Peptides
NCBI/Uniprot data below describe general gene information for TAC3. It may not necessarily be applicable to this product.
NCBI Accession #
AAF76980.1
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UniProt Primary Accession #
Q9UHF0
[Other Products]
UniProt Secondary Accession #
Q6IAG2; Q71BC6; Q71BC9[Other Products]
UniProt Related Accession #
Q9UHF0[Other Products]
Molecular Weight
13,438 Da[Similar Products]
NCBI Official Full Name
neurokinin B
NCBI Official Synonym Full Names
tachykinin 3
NCBI Official Symbol
TAC3??[Similar Products]
NCBI Official Synonym Symbols
NKB; HH10; NKNB; PRO1155; ZNEUROK1
??[Similar Products]
NCBI Protein Information
tachykinin-3; neuromedin K; gamma tachykinin 3; preprotachykinin B; preprotachykinin-B
UniProt Protein Name
Tachykinin-3
UniProt Synonym Protein Names
ZNEUROK1Cleaved into the following chain:Neurokinin-B; NKB; Alternative name(s):; Neuromedin-K
Protein Family
Neurokinin
UniProt Gene Name
TAC3??[Similar Products]
UniProt Synonym Gene Names
NKNB; NKB??[Similar Products]
UniProt Entry Name
TKNK_HUMAN
NCBI Summary for TAC3
This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded protein is primarily expressed in the central and peripheral nervous system and functions as a neurotransmitter. This protein is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
UniProt Comments for TAC3
TAC3: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Belongs to the tachykinin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 12q13.3
Cellular Component: extracellular space; extracellular region
Molecular Function: protein binding; receptor binding
Biological Process: tachykinin signaling pathway; neuropeptide signaling pathway; female pregnancy
Disease: Hypogonadotropic Hypogonadism 10 With Or Without Anosmia
Research Articles on TAC3
1. Rare variants in the TAC3 and TACR3 genes were identified in patients with central pubertal disorders and loss-of-function variants of TACR3 were associated with the normosmic IHH phenotype.
Precautions
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Disclaimer
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