Full Product Name
Anti-ERCC8 Antibody
Product Gene Name
anti-ERCC8 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Immunogen
Recombinant protein of human ERCC8
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-ERCC8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ERCC8 antibody
This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH.
Applications Tested/Suitable for anti-ERCC8 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ERCC8 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
NCBI/Uniprot data below describe general gene information for ERCC8. It may not necessarily be applicable to this product.
NCBI Accession #
ALQ33438.1
[Other Products]
UniProt Secondary Accession #
Q6FHX5; Q96GB9; B2RB64[Other Products]
UniProt Related Accession #
Q13216[Other Products]
Molecular Weight
23,182 Da
NCBI Official Full Name
excision repair cross-complementing rodent repair deficiency complementation group 8 isoform 3
NCBI Official Synonym Full Names
ERCC excision repair 8, CSA ubiquitin ligase complex subunit
NCBI Official Symbol
ERCC8??[Similar Products]
NCBI Official Synonym Symbols
CSA; CKN1; UVSS2
??[Similar Products]
NCBI Protein Information
DNA excision repair protein ERCC-8
UniProt Protein Name
DNA excision repair protein ERCC-8
UniProt Synonym Protein Names
Cockayne syndrome WD repeat protein CSA
Protein Family
DNA excision repair protein
UniProt Gene Name
ERCC8??[Similar Products]
UniProt Synonym Gene Names
CKN1; CSA??[Similar Products]
NCBI Summary for ERCC8
This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]
UniProt Comments for ERCC8
Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes.
Research Articles on ERCC8
1. ERCC6 rs1917799, ERCC8 rs158572 and rs158916 demonstrated pairwise epistatic interactions to associate with chronic atrophic gastritis and gastric cancer risk. The ERCC6 rs1917799-ERCC8 rs158572 pair significantly influence ERCC6 and ERCC6-ERCC8 expression.
Precautions
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Disclaimer
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