Grik3, Glutamate receptor ionotropic kainate 3, glutamate receptor 7, gluR7, excitatory amino acid receptor 5, eea5

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Affinity chromatography purified via peptide column

Supplied in PBS containing 0.02% sodium azide.

Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Small volumes of anti-Grik3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik3, also known as glutamate receptor 7, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik3 is highly homologous to the related ionotrophic glutamate receptors Grik2 and Grik1. Grik3 has recently been shown to be an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses as grik3-null mice show significantly reduced short- and long-term synaptic potentiation. Other reports have suggested that different polymorphisms in the Grik3 protein may be associated with neurological defects such as recurrent major depressive disorder and schizophrenia. This Grik3 antibody does not cross-react with Grik2.

Total protein Ab

ELISA (EIA), Western Blot (WB)

Western blot analysis of Grik3 in human brain tissue lysate with Grik3 antibody at (A) 1 and (B) 2 ug/mL.

98,727 Da

Glutamate receptor ionotropic, kainate 3

GLUR7; GluK3; EAA5; GluR-7; GluR7??[Similar Products]

GRIK3_HUMAN

GluR7: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK3 subfamily.

Protein type: Channel, ligand-gated; Membrane protein, multi-pass; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: dendrite cytoplasm; presynaptic membrane; postsynaptic membrane; kainate selective glutamate receptor complex; integral to plasma membrane; axon; dendrite; plasma membrane; terminal button; perikaryon; cell junction

Molecular Function: adenylate cyclase inhibiting metabotropic glutamate receptor activity; kainate selective glutamate receptor activity; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity; glutamate receptor activity

Biological Process: synaptic transmission; synaptic transmission, glutamatergic; regulation of membrane potential; glutamate signaling pathway; ionotropic glutamate receptor signaling pathway; metabotropic glutamate receptor signaling pathway; negative regulation of synaptic transmission, glutamatergic; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway

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