Product Name
Noggin (NOG), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Noggin (NOG)
Product Gene Name
anti-NOG antibody
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APC Conjugated Antibody: Noggin (NOG) (MBS2063444)
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FITC Conjugated Antibody: Noggin (NOG) (MBS2063446)
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Matching Pairs
Unconjugated Antibody: Noggin (NOG) (MBS2003895)
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF-QHYL HIRPAPSDNL PLVDLIEHPD PIFDPKEKDL NETLLRSLMG GHFDPNFMAM SLPEDRLGVD DLAELDLLLR QRPSGAMPGE IKGLEFYDGL QPGKKHRLSK KLRRKLQMWL WSQTFCPVLY TWNDLGSRFW PRYVKVGSCY SKRSCSVPEG MVCKPAKSVH LTILRWRCQR RGGQRCTWIP IQYPIIAECK CSC
3D Structure
ModBase 3D Structure for O93525
Species Reactivity
Chicken
Specificity
The antibody is a rabbit polyclonal antibody raised against NOG. It has been selected for its ability to recognize NOG in immunohistochemical staining andwestern blotting.
Purity/Purification
Affinity Chromatography
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Concentration
200ug/ml (lot specific)
Immunogen
Recombinant NOG (Gln27~Cys223) expressed in E.coli.
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2063444
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customera??s specifications, please inquire.
Other Notes
Small volumes of anti-NOG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-NOG antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-NOG antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB) of anti-NOG antibody
Western Blot: Sample: Recombinant protein.
NCBI/Uniprot data below describe general gene information for NOG. It may not necessarily be applicable to this product.
NCBI Accession #
NP_989454.1
[Other Products]
NCBI GenBank Nucleotide #
NM_204123.1
[Other Products]
UniProt Primary Accession #
O93525
[Other Products]
UniProt Secondary Accession #
O73674[Other Products]
UniProt Related Accession #
O93525[Other Products]
Molecular Weight
25,596 Da
NCBI Official Full Name
noggin
NCBI Official Synonym Full Names
noggin
NCBI Official Symbol
NOG??[Similar Products]
NCBI Protein Information
noggin
UniProt Protein Name
Noggin
UniProt Synonym Protein Names
cNoggin
UniProt Gene Name
NOG??[Similar Products]
UniProt Comments for NOG
Inhibitor of bone morphogenetic proteins (BMP) signaling. Controls somitogenesis by sequestering the BMP-4 activity which in turn differentiates distinct subtypes of the mesoderm along the mediolateral axis.
Research Articles on NOG
1. Noggin overexpression resulted in disrupted cord organization, and dilated sinusoidal space, eventually leading to increased apoptosis and failed hepatocyte differentiation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
