Mouse Prolyl 3-hydroxylase 1 (LEPRE1) ELISA kit; GROS1; MGC117314; OI8; P3H1; growth suppressor 1; leprecan; leprecan 1; prolyl 3-hydroxylase 1; leucine proline-enriched proteoglycan (leprecan) 1

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of LEPRE1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9341001 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the leucine proline-enriched proteoglycan (leprecan) 1 (LEPRE1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing LEPRE1. The ELISA analytical biochemical technique of the MBS9341001 kit is based on LEPRE1 antibody-LEPRE1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect LEPRE1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, LEPRE1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

83,651 Da

leprecan 1

prolyl 3-hydroxylase 1; leprecan-1; growth suppressor 1; leucine- and proline-enriched proteoglycan 1

Prolyl 3-hydroxylase 1

Gros1; P3h1; Leprecan-1??[Similar Products]

P3H1_MOUSE

LEPRE1: Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro- Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts. Defects in LEPRE1 are the cause of osteogenesis imperfecta type 8 (OI8). A connective tissue disorder characterized by disproportionate short stature, severe osteoporosis, shortening of the long bones, white sclerae, a round face and a short barrel-shaped chest. Belongs to the leprecan family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; Secreted; Secreted, signal peptide; Oxidoreductase; EC 1.14.11.7

Cellular Component: proteinaceous extracellular matrix; membrane; endoplasmic reticulum; cytoplasm; extracellular region; plasma membrane; basement membrane; nucleus

Molecular Function: procollagen-proline 3-dioxygenase activity; dioxygenase activity; L-ascorbic acid binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; metal ion binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; oxidoreductase activity

Biological Process: regulation of protein secretion; collagen fibril organization; protein folding; protein stabilization; collagen metabolic process; peptidyl-proline hydroxylation; protein amino acid hydroxylation; regulation of ossification; cell growth

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