Product Name
SLC19A3, Polyclonal Antibody
Full Product Name
SLC19A3 Antibody, HRP conjugated
Product Synonym Names
Thiamine transporter 2; ThTr-2; ThTr2; Solute carrier family 19 member 3; SLC19A3
Product Gene Name
anti-SLC19A3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9BZV2
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Thiamine transporter 2 protein (191-282AA)
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-SLC19A3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SLC19A3 antibody
Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity.
Product Categories/Family for anti-SLC19A3 antibody
Others
Applications Tested/Suitable for anti-SLC19A3 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for SLC19A3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_079519.1
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NCBI GenBank Nucleotide #
NM_025243.3
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UniProt Primary Accession #
Q9BZV2
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UniProt Related Accession #
Q9BZV2[Other Products]
Molecular Weight
55,665 Da
NCBI Official Full Name
thiamine transporter 2
NCBI Official Synonym Full Names
solute carrier family 19 member 3
NCBI Official Symbol
SLC19A3??[Similar Products]
NCBI Official Synonym Symbols
BBGD; THMD2; THTR2
??[Similar Products]
NCBI Protein Information
thiamine transporter 2
UniProt Protein Name
Thiamine transporter 2
UniProt Synonym Protein Names
Solute carrier family 19 member 3
Protein Family
Thiamine transporter
UniProt Gene Name
SLC19A3??[Similar Products]
UniProt Synonym Gene Names
ThTr-2; ThTr2??[Similar Products]
NCBI Summary for SLC19A3
This gene encodes a ubiquitously expressed transmembrane thiamine transporter that lacks folate transport activity. Mutations in this gene cause biotin-responsive basal ganglia disease (BBGD); a recessive disorder manifested in childhood that progresses to chronic encephalopathy, dystonia, quadriparesis, and death if untreated. Patients with BBGD have bilateral necrosis in the head of the caudate nucleus and in the putamen. Administration of high doses of biotin in the early progression of the disorder eliminates pathological symptoms while delayed treatment results in residual paraparesis, mild cognitive disability, or dystonia. Administration of thiamine is ineffective in the treatment of this disorder. Experiments have failed to show that this protein can transport biotin. Mutations in this gene also cause a Wernicke's-like encephalopathy.[provided by RefSeq, Jan 2010]
UniProt Comments for SLC19A3
Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity.
Research Articles on SLC19A3
1. two siblings who received a refined diagnosis of BTBGD following whole-genome sequencing. Both children inherited compound heterozygous mutations from unaffected parents; a missense single-nucleotide variant (p.G23V) in the first transmembrane domain of the protein, and a 4808-bp deletion in exon 1 encompassing the 5' UTR and minimal promoter region.
Precautions
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