Product Name
FLVCR1, cDNA Clone
Full Product Name
FLVCR1 cDNA Clone
Product Gene Name
FLVCR1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggcgcggc cagacgatga ggagggggcg gcggtggcgc ccggacaccc gctcgcgaaa ggatacctcc cgttgccgag gggcgcgccc gttgggaagg agagcgtgga gctgcagaac gggcccaaag cgggcacctt cccggtgaat gggccccccc gggacagcct cgctgccgcc tcgggagttc tgggcgggcc tcagactcca ctggccccag aagaggagac ccaggcccgg ctgctgcctg cgggcgcggg agctgagacc ccgggggccg agagcagccc gctgcccctt acggcgctct ccccgcggcg cttcgtggtg ctcctgatct tcagcctgta ctcgctggtc aacgcctttc agtggatcca gtacagcatc attagcaacg tcttcgaggg cttctacggt gtcaccttgc tgcacatcga ctggctgtcc atggtgtaca tgctggccta cgtgcccctc atcttcccgg ccacctggct gctggacacc agaggcctgc ggctcaccgc cctgctgggc tccggcctca actgcctggg tgcctggatc aagtgcggca gtgtgcagca gcatctcttc tgggtcacca tgttgggcca gtgcttgtgc tcggtggccc aggtgttcat cctgggcttg ccctcccgca tcgcctcagt gtggtttggg cccaaagagg tgtccacagc ttgtgccacc gccgtgctgg gcaatcagct tggaactgca gttggctttt tgctaccacc agttttagta cccaacacac agaatgacac aaatctcctg gcttgtaata tcagcaccat gttttatgga acatcagctg ttgccacact tttatttatt ttaacagcaa ttgccttcaa agaaaaacct cggtatccac caagtcaggc tcaagcagct cttcaagaca gtccccctga agagtactcc tataagaaat caataagaaa cctgtttaaa aacattcctt ttgtccttct gttgatcact tatggtatca tgactggtgc cttttattca gtctcaacgt tattaaatca aatgatattg acatattatg agggagaaga agtcaatgct ggaaggattg ggctaacgct agtagtagct ggaatggtgg gctctattct ttgtggctta tggctggatt atactaaaac atacaaacag actactctga tagtttatat tttgtctttt attggaatgg ttatctttac tttcacattg gaccttagat acattatcat cgtgtttgtt actggagggg tgcttggctt cttcatgact ggttacctcc ctttgggttt tgaatttgct gttgaaatca cttaccctga atctgaaggt acttcatctg gtcttcttaa tgcttctgca cagatatttg gaattttgtt cacattggct caaggaaagc tcacatcaga ctatggtcct aaggcaggga acatttttct ctgtgtctgg atgtttatag gcatcatatt aacagcatta atcaagtctg atctgcgaag acacaacata aatataggaa ttacaaatgt tgatgttaaa gctataccag ctgacagtcc cacagaccaa gaaccaaaaa tggttatgtt gtccaagcag tcagaatcag caatttga
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of FLVCR1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for FLVCR1. It may not necessarily be applicable to this product.
NCBI Accession #
BC048312
[Other Products]
UniProt Secondary Accession #
Q1HE16; Q86XY9; Q9NVR9[Other Products]
UniProt Related Accession #
Q9Y5Y0[Other Products]
Molecular Weight
30,744 Da
NCBI Official Full Name
Homo sapiens feline leukemia virus subgroup C cellular receptor 1, mRNA
NCBI Official Synonym Full Names
feline leukemia virus subgroup C cellular receptor 1
NCBI Official Symbol
FLVCR1??[Similar Products]
NCBI Official Synonym Symbols
PCA; AXPC1; FLVCR; PCARP; MFSD7B
??[Similar Products]
NCBI Protein Information
feline leukemia virus subgroup C receptor-related protein 1
UniProt Protein Name
Feline leukemia virus subgroup C receptor-related protein 1
Protein Family
Feline leukemia virus subgroup C receptor-related protein
UniProt Gene Name
FLVCR1??[Similar Products]
UniProt Synonym Gene Names
FLVCR; Feline leukemia virus subgroup C receptor; hFLVCR??[Similar Products]
UniProt Entry Name
FLVC1_HUMAN
NCBI Summary for FLVCR1
This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein is a heme transporter that may play a critical role in erythropoiesis by protecting developing erythroid cells from heme toxicity. This gene may play a role in posterior column ataxia with retinitis pigmentosa and the hematological disorder Diamond-Blackfan syndrome. [provided by RefSeq, Jan 2011]
UniProt Comments for FLVCR1
FLVCR1: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and may be required to protect developing erythroid cells from heme toxicity. Heme export also provides protection from heme or ferrous iron toxicities in liver and brain. Causes susceptibility to FeLV-C in vitro. Defects in FLVCR1 are the cause of posterior column ataxia with retinitis pigmentosa (PCARP). A neurodegenerative syndrome beginning in infancy with areflexia and retinitis pigmentosa. Nyctalopia (night blindness) and peripheral visual field loss are usually evident during late childhood or teenage years, with subsequent progressive constriction of the visual fields and loss of central retinal function over time. A sensory ataxia caused by degeneration of the posterior columns of the spinal cord results in a loss of proprioceptive sensation that is clinically evident in the second decade of life and gradually progresses. Scoliosis, camptodactyly, achalasia, gastrointestinal dysmotility, and a sensory peripheral neuropathy are variable features of the disease. Affected individuals have no clinical or radiological evidence of cerebral or cerebellar involvement. Defective neuronal heme transmembrane export due to FLVCR1 mutations may abrogate the neuroprotective effects of neuroglobin and initiate an apoptotic cascade that results in the selective degeneration of photoreceptors in the neurosensory retina and sensory neurons in the posterior spinal cord. Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family.
Protein type: Transporter; Membrane protein, integral; Transporter, ion channel; Transporter, iron; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1q32.3
Cellular Component: integral to plasma membrane; mitochondrion; plasma membrane
Molecular Function: heme transporter activity; protein binding; transporter activity
Biological Process: cellular iron ion homeostasis; erythrocyte differentiation; heme transport; mitochondrial transport; multicellular organismal development; transport
Disease: Posterior Column Ataxia With Retinitis Pigmentosa
Research Articles on FLVCR1
1. Flvcr1 regulates differentiation of erythroid progenitors by controlling intracellular heme accumulation.
Precautions
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Disclaimer
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