FLVCR1; feline leukemia virus subgroup C cellular receptor; FLVCR protein; FLVCR; eline leukemia virus subgroup C cellular receptor 1; FLVCR antibody; feline leukemia virus subgroup C cellular receptor antibody; FLVCR protein antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Goat

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul (lot specific)

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of anti-FLVCR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Peptide ELISA (EIA), Western Blot (WB)

Peptide ELISA: Antibody detection limit dilution 1: 128000.

(0.1ug/ml) staining of Human Bone Marrow lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

30,744 Da

feline leukemia virus subgroup C cellular receptor 1

feline leukemia virus subgroup C receptor-related protein 1

Feline leukemia virus subgroup C receptor-related protein 1

FLVCR; Feline leukemia virus subgroup C receptor; hFLVCR??[Similar Products]

FLVC1_HUMAN

This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein is a heme transporter that may play a critical role in erythropoiesis by protecting developing erythroid cells from heme toxicity. This gene may play a role in posterior column ataxia with retinitis pigmentosa and the hematological disorder Diamond-Blackfan syndrome. [provided by RefSeq, Jan 2011]

FLVCR1: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and may be required to protect developing erythroid cells from heme toxicity. Heme export also provides protection from heme or ferrous iron toxicities in liver and brain. Causes susceptibility to FeLV-C in vitro. Defects in FLVCR1 are the cause of posterior column ataxia with retinitis pigmentosa (PCARP). A neurodegenerative syndrome beginning in infancy with areflexia and retinitis pigmentosa. Nyctalopia (night blindness) and peripheral visual field loss are usually evident during late childhood or teenage years, with subsequent progressive constriction of the visual fields and loss of central retinal function over time. A sensory ataxia caused by degeneration of the posterior columns of the spinal cord results in a loss of proprioceptive sensation that is clinically evident in the second decade of life and gradually progresses. Scoliosis, camptodactyly, achalasia, gastrointestinal dysmotility, and a sensory peripheral neuropathy are variable features of the disease. Affected individuals have no clinical or radiological evidence of cerebral or cerebellar involvement. Defective neuronal heme transmembrane export due to FLVCR1 mutations may abrogate the neuroprotective effects of neuroglobin and initiate an apoptotic cascade that results in the selective degeneration of photoreceptors in the neurosensory retina and sensory neurons in the posterior spinal cord. Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family.

Protein type: Membrane protein, multi-pass; Transporter, ion channel; Transporter; Membrane protein, integral; Transporter, iron

Chromosomal Location of Human Ortholog: 1q32.3

Cellular Component: integral to plasma membrane; mitochondrial membrane; mitochondrion; plasma membrane

Molecular Function: heme transporter activity; protein binding; transporter activity

Biological Process: blood vessel development; cellular iron ion homeostasis; embryonic digit morphogenesis; embryonic skeletal morphogenesis; erythrocyte differentiation; erythrocyte maturation; heme transport; in utero embryonic development; mitochondrial transport; multicellular organism growth; multicellular organismal development; regulation of organ growth; spleen development; transmembrane transport; transport

Disease: Posterior Column Ataxia With Retinitis Pigmentosa

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