Full Product Name
FLVC1 Polyclonal Antibody
Product Synonym Names
Feline leukemia virus subgroup C receptor-related protein 1; Feline leukemia virus subgroup C receptor; hFLVCR; FLVCR1; FLVCR
Product Gene Name
anti-FLVC1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9Y5Y0
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Immunogen
Synthesized peptide derived from human protein. at AA range: 481-530
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-FLVC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-FLVC1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-FLVC1 antibody
WB: 1:500-2000
ELISA: 1:5000-20000
NCBI/Uniprot data below describe general gene information for FLVC1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_054772.1
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NCBI GenBank Nucleotide #
NM_014053.3
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UniProt Primary Accession #
Q9Y5Y0
[Other Products]
UniProt Secondary Accession #
Q1HE16; Q86XY9; Q9NVR9[Other Products]
UniProt Related Accession #
Q9Y5Y0[Other Products]
NCBI Official Full Name
feline leukemia virus subgroup C receptor-related protein 1
NCBI Official Synonym Full Names
feline leukemia virus subgroup C cellular receptor 1
NCBI Official Symbol
FLVCR1??[Similar Products]
NCBI Official Synonym Symbols
PCA; AXPC1; FLVCR; PCARP; MFSD7B
??[Similar Products]
NCBI Protein Information
feline leukemia virus subgroup C receptor-related protein 1
UniProt Protein Name
Feline leukemia virus subgroup C receptor-related protein 1
UniProt Gene Name
FLVCR1??[Similar Products]
UniProt Synonym Gene Names
FLVCR; Feline leukemia virus subgroup C receptor; hFLVCR??[Similar Products]
NCBI Summary for FLVC1
This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein is a heme transporter that may play a critical role in erythropoiesis by protecting developing erythroid cells from heme toxicity. This gene may play a role in posterior column ataxia with retinitis pigmentosa and the hematological disorder Diamond-Blackfan syndrome. [provided by RefSeq, Jan 2011]
UniProt Comments for FLVC1
Isoform 1: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during er****opoiesis, a process in which heme synthesis intensifies. Causes susceptibility to FeLV-C in vitro.
Research Articles on FLVC1
1. Mutation in FLVCR1 gene is associated with Posterior column ataxia with retinitis pigmentosa coexisting with sensory-autonomic neuropathy and leukemia.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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