Human Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1) ELISA kit; FLVCR; ; feline leukemia virus subgroup C cellular receptor 1

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of FLVCR1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9331658 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the feline leukemia virus subgroup C cellular receptor 1 (FLVCR1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing FLVCR1. The ELISA analytical biochemical technique of the MBS9331658 kit is based on FLVCR1 antibody-FLVCR1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FLVCR1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FLVCR1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

59,863 Da

feline leukemia virus subgroup C cellular receptor 1

feline leukemia virus subgroup C receptor-related protein 1

Feline leukemia virus subgroup C receptor-related protein 1

FLVCR; Feline leukemia virus subgroup C receptor; hFLVCR??[Similar Products]

FLVC1_HUMAN

This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein is a heme transporter that may play a critical role in erythropoiesis by protecting developing erythroid cells from heme toxicity. This gene may play a role in posterior column ataxia with retinitis pigmentosa and the hematological disorder Diamond-Blackfan syndrome. [provided by RefSeq, Jan 2011]

FLVCR1: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and may be required to protect developing erythroid cells from heme toxicity. Heme export also provides protection from heme or ferrous iron toxicities in liver and brain. Causes susceptibility to FeLV-C in vitro. Defects in FLVCR1 are the cause of posterior column ataxia with retinitis pigmentosa (PCARP). A neurodegenerative syndrome beginning in infancy with areflexia and retinitis pigmentosa. Nyctalopia (night blindness) and peripheral visual field loss are usually evident during late childhood or teenage years, with subsequent progressive constriction of the visual fields and loss of central retinal function over time. A sensory ataxia caused by degeneration of the posterior columns of the spinal cord results in a loss of proprioceptive sensation that is clinically evident in the second decade of life and gradually progresses. Scoliosis, camptodactyly, achalasia, gastrointestinal dysmotility, and a sensory peripheral neuropathy are variable features of the disease. Affected individuals have no clinical or radiological evidence of cerebral or cerebellar involvement. Defective neuronal heme transmembrane export due to FLVCR1 mutations may abrogate the neuroprotective effects of neuroglobin and initiate an apoptotic cascade that results in the selective degeneration of photoreceptors in the neurosensory retina and sensory neurons in the posterior spinal cord. Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family.

Protein type: Membrane protein, integral; Transporter, ion channel; Transporter, iron; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 1q32.3

Cellular Component: mitochondrion; integral to plasma membrane; mitochondrial membrane; plasma membrane

Molecular Function: protein binding; transporter activity; heme transporter activity

Biological Process: spleen development; blood vessel development; heme transport; erythrocyte maturation; cellular iron ion homeostasis; in utero embryonic development; multicellular organismal development; multicellular organism growth; regulation of organ growth; mitochondrial transport; embryonic skeletal morphogenesis; transport; erythrocyte differentiation; embryonic digit morphogenesis; transmembrane transport

Disease: Posterior Column Ataxia With Retinitis Pigmentosa

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