Full Product Name
Anti-Rat CD25 PE (Clone OX-39) (mouse IgG1)
Product Synonym Names
CD25 PE (Clone OX-39) (mouse IgG1); PE Anti-Rat CD25 (IL-2R) Monoclonal Antibody
Product Gene Name
anti-CD25 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P25094
Specificity
CD25 (IL-2Ra) (Rat CD25 (IL-2R))
Form/Format
PE (R-PE conjugated Ig buffered in PBS, 0.02% NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml. (Purified from ascitic fluid via Protein G Chromatography))
Concentration
Antibody Concentration: 0.1 mg/ml (lot specific)
Immunogen
T blasts from a mixed lymphocyte reaction between purified CD4 positive T cells and irradiated spleens. Donor: BALB/c spleen
Presentation
50 ug or 200 ug PE conjugated Ig buffered in PBS, 0.02% NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml.
Preparation and Storage
Store at 4 degree C. DO NOT FREEZE. Avoid prolonged exposure to light.
Other Notes
Small volumes of anti-CD25 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD25 antibody
anti-rat Interleukin-2 receptor monoclonal antibody recognizes the smaller (alpha subunit) 55kD chain of the IL-2 receptor found on activated rat T cells, thymic dendritic cells but not resting lymphocytes (1). MBS520075 binds to the rat interleukin-2 receptor and has proven to be an important marker for activated T cells. (2). This clone is reported to work with frozen and paraffin sections (3).
Applications Tested/Suitable for anti-CD25 antibody
Immunohistochemistry (IHC)
Testing Data of anti-CD25 antibody
NCBI/Uniprot data below describe general gene information for CD25. It may not necessarily be applicable to this product.
NCBI Accession #
CAA44297.1
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UniProt Primary Accession #
P25094
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Molecular Weight
17,946 Da
NCBI Official Full Name
CD25
UniProt Protein Name
Peripheral myelin protein 22
UniProt Synonym Protein Names
Protein CD25; SR13 myelin protein; Schwann cell membrane glycoprotein
UniProt Gene Name
Pmp22??[Similar Products]
UniProt Synonym Gene Names
Cd25; Pmp-22; PMP-22; SAG??[Similar Products]
UniProt Entry Name
PMP22_RAT
UniProt Comments for CD25
Function: Might be involved in growth regulation, and in myelinization in the peripheral nervous system.
Subcellular location: Cell membrane; Multi-pass membrane protein
By similarity.
Tissue specificity: Found exclusively in the peripheral nervous system. Present in both myelinating and nonmyelinating Schwann cells. Found in the tumors of Schwann cell lineage where axons are present (neurofibromas) but not where axons are absent (schwannomas). Ref.4
Developmental stage: Levels increase between embryonic day 21 (E21) and postnatal day 0 (PND0) and then gradually increase up to PND15. There is a slight increase between PND15 and *****hood. Ref.4
Induction: Strongly down-regulated in the initial phase after sciatic nerve injury.
Sequence similarities: Belongs to the PMP-22/EMP/MP20 family.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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