Product Name
Anosmin (KAL1), Polyclonal Antibody
Full Product Name
Anti-Anosmin Antibody
Product Synonym Names
ADMLX; KAL; KALIG1; Anosmin-1; Adhesion molecule-like X-linked; Kallmann syndrome protein
Product Gene Name
anti-KAL1 antibody
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Antibody/Peptide Pairs
Anosmin peptide (MBS823065) is used for blocking the activity of Anosmin antibody (MBS821684)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P23352
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes endogenous levels of Anosmin protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Anosmin. The exact sequence is proprietary.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-KAL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KAL1 antibody
Rabbit polyclonal antibody to Anosmin
Applications Tested/Suitable for anti-KAL1 antibody
Western Blot (WB)
Application Notes for anti-KAL1 antibody
WB (1/500 - 1/1000)
Western Blot (WB) of anti-KAL1 antibody
Western blot analysis of Anosmin expression in Jurkat (A), mouse heart (B), rat heart (C) whole cell lysates.
NCBI/Uniprot data below describe general gene information for KAL1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000207.2
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NCBI GenBank Nucleotide #
NM_000216.2
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UniProt Primary Accession #
P23352
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UniProt Secondary Accession #
B2RPF8[Other Products]
UniProt Related Accession #
P23352[Other Products]
Molecular Weight
76,112 Da
NCBI Official Full Name
anosmin-1
NCBI Official Synonym Full Names
Kallmann syndrome 1 sequence
NCBI Official Symbol
KAL1??[Similar Products]
NCBI Official Synonym Symbols
HH1; HHA; KAL; KMS; ADMLX; WFDC19; KALIG-1
??[Similar Products]
NCBI Protein Information
anosmin-1; kallmann syndrome protein; adhesion molecule-like X-linked; Kallmann syndrome interval gene 1; WAP four-disulfide core domain 19; Kallmann syndrome-1 sequence (anosmin-1)
UniProt Protein Name
Anosmin-1
UniProt Synonym Protein Names
Adhesion molecule-like X-linked; Kallmann syndrome protein
UniProt Gene Name
KAL1??[Similar Products]
UniProt Synonym Gene Names
ADMLX; KAL; KALIG1??[Similar Products]
UniProt Entry Name
KALM_HUMAN
NCBI Summary for KAL1
Mutations in this gene cause the X-linked Kallmann syndrome. The encoded protein is similar in sequence to proteins known to function in neural cell adhesion and axonal migration. In addition, this cell surface protein is N-glycosylated and may have anti-protease activity. [provided by RefSeq, Jul 2008]
UniProt Comments for KAL1
KAL1: Has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex. Chemoattractant for fetal olfactory epithelial cells. Defects in KAL1 are the cause of Kallmann syndrome type 1 (KAL1); also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin- releasing hormone-synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous.
Protein type: Motility/polarity/chemotaxis; Extracellular matrix
Chromosomal Location of Human Ortholog: Xp22.32
Cellular Component: proteinaceous extracellular matrix; extracellular space; plasma membrane
Molecular Function: heparin binding; serine-type endopeptidase inhibitor activity; protein binding; extracellular matrix structural constituent
Biological Process: axon guidance; cell adhesion; chemotaxis; cell motility
Disease: Hypogonadotropic Hypogonadism 1 With Or Without Anosmia
Research Articles on KAL1
1. anosmin-1 has been identified in other pathological scenarios both within (multiple sclerosis) and outside (cancer, atopic dermatitis) the central nerve system.
Precautions
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Disclaimer
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