potassium voltage-gated channel; Isk-related family; member 1; KCNE1; FLJ18426; FLJ38123; FLJ94103; ISK; JLNS; JLNS2; LQT2/5; LQT5; MGC33114; MinK

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen Affinity Purified

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-KCNE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

14,675 Da[Similar Products]

potassium voltage-gated channel, Isk-related family, member 1

potassium voltage-gated channel subfamily E member 1; minimal potassium channel; delayed rectifier potassium channel subunit IsK; voltage gated potassiun channel accessory subunit; cardiac delayed rectifier potassium channel protein; potassium voltage-gated channel, Isk-related subfamily, member 1; IKs producing slow voltage-gated potassium channel subunit beta Mink

Potassium voltage-gated channel subfamily E member 1

KCNE1_HUMAN

The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

KCNE1: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Associates with KCNQ1/KVLQT1 and KCNH2/HERG. Expressed in heart, lung, kidney, testis, ovaries, small intestine, peripheral blood leukocytes. Not detected in pancreas, spleen, prostate and colon. Restrictively localized in the apical membrane portion of epithelial cells. Belongs to the potassium channel KCNE family.

Protein type: Membrane protein, integral; Channel, potassium

Chromosomal Location of Human Ortholog: 21q22.12

Cellular Component: voltage-gated potassium channel complex; cell surface; lysosome; apical plasma membrane; plasma membrane; Z disc

Molecular Function: voltage-gated potassium channel activity; protein binding; potassium channel regulator activity; telethonin binding; delayed rectifier potassium channel activity

Biological Process: protein amino acid O-linked glycosylation; sensory perception of sound; protein amino acid N-linked glycosylation

Disease: Jervell And Lange-nielsen Syndrome 2; Long Qt Syndrome 5

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