Product Name
Cytochrome P450 7B1 (CP7B1), Antibody
Full Product Name
Cytochrome P450 7B1 Antibody
Product Synonym Names
25-hydroxycholesterol 7-alpha-hydroxylase; CP7B; cytochrome P450 7B1; cytochrome P450, 7, B, 1; EC 1.14.13.100; oxysterol 7-alpha-hydroxylase
Product Gene Name
anti-CP7B1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O75881
Specificity
Cytochrome P450 7B1 Antibody detects endogenous levels of total Cytochrome P450 7B1
Purity/Purification
Immunogen affinity purified
Form/Format
In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
A synthesized peptide
Preparation and Storage
Store at-20 degree C for 1 year
Other Notes
Small volumes of anti-CP7B1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CP7B1 antibody
Western Blot (WB)
Application Notes for anti-CP7B1 antibody
WB: 1:500-1:1000
Western Blot (WB) of anti-CP7B1 antibody
Western blot analysis of extracts from LOVO cells, using Cytochrome P450 7B1 antibody.
NCBI/Uniprot data below describe general gene information for CP7B1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004811.1
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NCBI GenBank Nucleotide #
NM_004820.4
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UniProt Primary Accession #
O75881
[Other Products]
UniProt Secondary Accession #
Q9UNF5; B2RN07[Other Products]
UniProt Related Accession #
O75881[Other Products]
NCBI Official Full Name
25-hydroxycholesterol 7-alpha-hydroxylase isoform 1
NCBI Official Synonym Full Names
cytochrome P450 family 7 subfamily B member 1
NCBI Official Symbol
CYP7B1??[Similar Products]
NCBI Official Synonym Symbols
CP7B; CBAS3; SPG5A
??[Similar Products]
NCBI Protein Information
25-hydroxycholesterol 7-alpha-hydroxylase
UniProt Protein Name
25-hydroxycholesterol 7-alpha-hydroxylase
UniProt Synonym Protein Names
Cytochrome P450 7B1; Oxysterol 7-alpha-hydroxylase
UniProt Gene Name
CYP7B1??[Similar Products]
NCBI Summary for CP7B1
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis. Mutations in this gene have been associated with hereditary spastic paraplegia (SPG5 or HSP), an autosomal recessive disorder. [provided by RefSeq, Apr 2016]
UniProt Comments for CP7B1
Oxysterol 7alpha-hydroxylase that mediates formation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) from 25-hydroxycholesterol (PubMed:10588945). Plays a key role in cell positioning and movement in lymphoid tissues: 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells ().
Research Articles on CP7B1
1. SPG11 and CYP7B1 were the most common cause of autosomal recessive hereditary spastic paraplegia in Greece.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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