Full Product Name
CHST3 Rabbit Polyclonal
Product Gene Name
anti-CHST3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Immunogen
Carbohydrate (chondroitin 6) sulfotransferase 3
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-CHST3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CHST3 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for CHST3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004264.2
[Other Products]
NCBI GenBank Nucleotide #
NM_004273.4
[Other Products]
UniProt Secondary Accession #
O75099; Q52M30[Other Products]
UniProt Related Accession #
Q7LGC8[Other Products]
Molecular Weight
54,706 Da
NCBI Official Full Name
carbohydrate sulfotransferase 3
NCBI Official Synonym Full Names
carbohydrate sulfotransferase 3
NCBI Official Symbol
CHST3??[Similar Products]
NCBI Official Synonym Symbols
HSD; C6ST; C6ST1
??[Similar Products]
NCBI Protein Information
carbohydrate sulfotransferase 3
UniProt Protein Name
Carbohydrate sulfotransferase 3
UniProt Synonym Protein Names
Chondroitin 6-O-sulfotransferase 1; C6ST-1; Chondroitin 6-sulfotransferase; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0; GST-0
Protein Family
Carbohydrate sulfotransferase
UniProt Gene Name
CHST3??[Similar Products]
UniProt Synonym Gene Names
C6ST-1; GST-0??[Similar Products]
UniProt Entry Name
CHST3_HUMAN
NCBI Summary for CHST3
This gene encodes an enzyme which catalyzes the sulfation of chondroitin, a proteoglycan found in the extracellular matrix and most cells which is involved in cell migration and differentiation. Mutations in this gene are associated with spondylepiphyseal dysplasia and humerospinal dysostosis. [provided by RefSeq, Mar 2009]
UniProt Comments for CHST3
CHST3: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N- acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen. Defects in CHST3 are a cause of spondyloepiphyseal dysplasia with congenital joint dislocations (SEDC-JD). A bone dysplasia clinically characterized by dislocation of the knees and/or hips at birth, clubfoot, elbow joint dysplasia with subluxation and limited extension, short stature, and progressive kyphosis developing in late childhood. The disorder is usually evident at birth, with short stature and multiple joint dislocations or subluxations that dominate the neonatal clinical and radiographic picture. During childhood, the dislocations improve, both spontaneously and with surgical treatment, and features of spondyloepiphyseal dysplasia become apparent, leading to arthritis of the hips and spine with intervertebral disk degeneration, rigid kyphoscoliosis, and trunk shortening by late childhood. Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
Protein type: Membrane protein, integral; Glycan Metabolism - chondroitin sulfate biosynthesis; EC 2.8.2.17; Transferase
Chromosomal Location of Human Ortholog: 10q22.1
Cellular Component: Golgi membrane; integral to membrane
Molecular Function: chondroitin 6-sulfotransferase activity; N-acetylglucosamine 6-O-sulfotransferase activity; proteoglycan sulfotransferase activity; sulfotransferase activity
Biological Process: axon regeneration in the peripheral nervous system; carbohydrate metabolic process; chondroitin sulfate biosynthetic process; positive regulation of cell motility; positive regulation of defense response to virus by host; sulfur metabolic process
Disease: Multiple Joint Dislocations, Short Stature, Craniofacial Dysmorphism, And Congenital Heart Defects; Spondyloepiphyseal Dysplasia With Congenital Joint Dislocations
Research Articles on CHST3
1. Sequencing of CHST3 detected a previously unreported homozygous duplication c.407_426dup (p.Thr143Cysfs*80). The mutation is predicted to lead to frameshift and introduction of a premature stopcodon.
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