Product Name
DPYS, cDNA Clone
Full Product Name
DPYS cDNA Clone
Product Gene Name
DPYS cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggcggcgc cctcgcggct cctgatccgc gggggtcgcg tggtcaacga tgacttctcg gaggtggccg acgtgctggt ggaggacggc gtggtgcggg cactcgggca cgacctgctg cctcccgggg gcgctcctgc ggggctgcgg gtcctcgacg ccgccggcaa gctcgtcctg cccggaggca tcgacacaca cacgcacatg cagttcccct tcatgggctc gcggtccatc gacgacttcc accagggcac caaggctgct ctctcaggag gcaccaccat gattattgat ttcgccattc ctcagaaagg tggctccctc attgaggcct tcgagacctg gcgaagctgg gctgatccca aagtttgctg cgactacagc cttcatgtgg cagtgacgtg gtggagtgac caggttaaag aagaaatgaa aatccttgtg caagataaag gtgttaactc tttcaagatg tttatggcct ataaagatct gtacatggtg acagacctgg agctgtacga agccttctct cggtgcaagg aaattggagc aattgcccag gtccatgcgg aaaatggaga cttaattgca gagggagcaa agaagatgtt ggctctgggg ataacaggcc ctgagggcca cgagctgtgc cgcccagagg cagtggaggc agaggccacg ctgagagcca tcaccatagc cagcgctgtg aactgtcctc tctacattgt gcatgtgatg agcaagtctg cagctaaggt gatagcggat gcaaggagag atgggaaggt ggtctatggt gaacccatag cagccagtct tggcacagat ggcactcact actggaataa agaatggcac catgcagccc accatgtcat gggtccacct ttgcgaccag acccctcaac acccgacttc ctcatgaatc tgttggctaa tgatgatcta accacaacag ggactgataa ctgcactttc aacacctgcc agaaagctct tgggaaggat gattttacca agatccccaa tggggtgaat ggtgttgaag atcggatgtc cgtaatatgg gaaaaaggcg tgcatagtgg taaaatggat gaaaacagat ttgtggcagt taccagcaca aatgcagcca aaatttttaa tctctatcca agaaaaggaa gaatagctgt aggatcagat gctgacattg ttatttggga cccaaaaggc acaaggacta tctcagcaaa aactcatcat caggctgtta acttcaacat tttcgagggc atggtttgcc acggggtgcc ccttgtgact atttcaagag gcaaagtggt atatgaagcc ggagtgttca gtgtcacggc aggagatggg aagtttattc ctcgaaaacc atttgctgaa tatatttaca aacgaataaa gcagcgagac cggacttgca cacctacccc tgtggagcgt gcaccctata agggagaagt cgccacactg aaatccagag tgacaaaaga agatgccaca gcagggacca ggaaacaggc ccacccctga
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of DPYS cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for DPYS. It may not necessarily be applicable to this product.
NCBI Accession #
BC034395
[Other Products]
UniProt Related Accession #
Q14117[Other Products]
Molecular Weight
56,630 Da
NCBI Official Full Name
Homo sapiens dihydropyrimidinase, mRNA
NCBI Official Synonym Full Names
dihydropyrimidinase
NCBI Official Symbol
DPYS??[Similar Products]
NCBI Official Synonym Symbols
DHP; DHPase
??[Similar Products]
NCBI Protein Information
dihydropyrimidinase
UniProt Protein Name
Dihydropyrimidinase
UniProt Synonym Protein Names
Dihydropyrimidine amidohydrolase; Hydantoinase
UniProt Gene Name
DPYS??[Similar Products]
UniProt Synonym Gene Names
DHP; DHPase??[Similar Products]
UniProt Entry Name
DPYS_HUMAN
NCBI Summary for DPYS
Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]
UniProt Comments for DPYS
DPYS: Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6- dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate. Defects in DPYS are the cause of dihydropyrimidinase deficiency (DHPD). DHPD is an autosomal recessive disorder characterized by dihydropyrimidinuria and associated with a variable clinical phenotype: epileptic or convulsive attacks, dysmorphic features and severe developmental delay, and congenital microvillous atrophy. Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
Protein type: Xenobiotic Metabolism - drug metabolism - other enzymes; Hydrolase; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Other Amino Acids Metabolism - beta-alanine; EC 3.5.2.2; Nucleotide Metabolism - pyrimidine
Chromosomal Location of Human Ortholog: 8q22
Cellular Component: cytosol
Molecular Function: dihydropyrimidinase activity
Biological Process: protein homotetramerization; pyrimidine base catabolic process; pyrimidine nucleoside catabolic process; thymine catabolic process; uracil catabolic process
Disease: Dihydropyrimidinase Deficiency
Research Articles on DPYS
1. Stepwise Cox regression modelling suggested that the methylation of genes HSPB1, CCND2 and DPYS contributed objective prognostic information to Gleason score and PSA with respect to prostate cancer-related death.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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