Product Name
CHRM3, cDNA Clone
Full Product Name
CHRM3 cDNA Clone
Product Gene Name
CHRM3 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ATGACCTTGC ACAATAACAG TACAACCTCG CCTTTGTTTC CAAACATCAG CTCCTCCTGG ATACACAGCC CCTCCGATGC AGGGCTGCCC CCGGGAACCG TCACTCATTT CGGCAGCTAC AATGTTTCTC GAGCAGCTGG CAATTTCTCC TCTCCAGACG GTACCACCGA TGACCCTCTG GGAGGTCATA CCGTCTGGCA AGTGGTCTTC ATCGCTTTCT TAACGGGCAT CCTGGCCTTG GTGACCATCA TCGGCAACAT CCTGGTAATT GTGTCATTTA AGGTCAACAA GCAGCTGAAG ACGGTCAACA ACTACTTCCT CTTAAGCCTG GCCTGTGCCG ATCTGATTAT CGGGGTCATT TCAATGAATC TGTTTACGAC CTACATCATC ATGAATCGAT GGGCCTTAGG GAACTTGGCC TGTGACCTCT GGCTTGCCAT TGACTACGTA GCCAGCAATG CCTCTGTTAT GAATCTTCTG GTCATCAGCT TTGACAGATA CTTTTCCATC ACGAGGCCGC TCACGTACCG AGCCAAACGA ACAACAAAGA GAGCCGGTGT GATGATCGGT CTGGCTTGGG TCATCTCCTT TGTCCTTTGG GCTCCTGCCA TCTTGTTCTG GCAATACTTT GTTGGAAAGA GAACTGTGCC TCCGGGAGAG TGCTTCATTC AGTTCCTCAG TGAGCCCACC ATTACTTTTG GCACAGCCAT CGCTGCTTTT TATATGCCTG TCACCATTAT GACTATTTTA TACTGGAGGA TCTATAAGGA AACTGAAAAG CGTACCAAAG AGCTTGCTGG CCTGCAAGCC TCTGGGACAG AGGCAGAGAC AGAAAACTTT GTCCACCCCA CGGGCAGTTC TCGAAGCTGC AGCAGTTACG AACTTCAACA GCAAAGCATG AAACGCTCCA ACAGGAGGAA GTATGGCCGC TGCCACTTCT GGTTCACAAC CAAGAGCTGG AAACCCAGCT CCGAGCAGAT GGACCAAGAC CACAGCAGCA GTGACAGTTG GAACAACAAT GATGCTGCTG CCTCCCTGGA GAACTCCGCC TCCTCCGACG AGGAGGACAT TGGCTCCGAG ACGAGAGCCA TCTACTCCAT CGTGCTCAAG CTTCCGGGTC ACAGCACCAT CCTCAACTCC ACCAAGTTAC CCTCATCGGA CAACCTGCAG GTGCCTGAGG AGGAGCTGGG GATGGTGGAC TTGGAGAGGA AAGCCGACAA GCTGCAGGCC CAGAAGAGCG TGGACGATGG AGGCAGTTTT CCAAAAAGCT TCTCCAAGCT TCCCATCCAG CTAGAGTCAG CCGTGGACAC AGCTAAGACT TCTGACGTCA ACTCCTCAGT GGGTAAGAGC ACGGCCACTC TACCTCTGTC CTTCAAGGAA GCCACTCTGG CCAAGAGGTT TGCTCTGAAG ACCAGAAGTC AGATCACTAA GCGGAAAAGG ATGTCCCTGG TCAAGGAGAA GAAAGCGGCC CAGACCCTCA GTGCGATCTT GCTTGCCTTC ATCATCACTT GGACCCCATA CAACATCATG GTTCTGGTGA ACACCTTTTG TGACAGCTGC ATACCCAAAA CCTTTTGGAA TCTGGGCTAC TGGCTGTGCT ACATCAACAG CACCGTGAAC CCCGTGTGCT ATGCTCTGTG CAACAAAACA TTCAGAACCA CTTTCAAGAT GCTGCTGCTG TGCCAGTGTG ACAAAAAAAA GAGGCGCAAG CAGCAGTACC AGCAGAGACA GTCGGTCATT TTTCACAAGC GCGCACCCGA GCAGGCCTTG TAG
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CHRM3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CHRM3. It may not necessarily be applicable to this product.
NCBI Accession #
BC121026
[Other Products]
UniProt Secondary Accession #
Q0VAJ8; Q4QRI3; Q5VXY2; Q9HB60[Other Products]
UniProt Related Accession #
P20309[Other Products]
Molecular Weight
66,128 Da
NCBI Official Full Name
Homo sapiens cholinergic receptor, muscarinic 3, mRNA
NCBI Official Synonym Full Names
cholinergic receptor muscarinic 3
NCBI Official Symbol
CHRM3??[Similar Products]
NCBI Official Synonym Symbols
HM3; PBS; EGBRS
??[Similar Products]
NCBI Protein Information
muscarinic acetylcholine receptor M3
UniProt Protein Name
Muscarinic acetylcholine receptor M3
Protein Family
Muscarinic acetylcholine receptor
UniProt Gene Name
CHRM3??[Similar Products]
UniProt Entry Name
ACM3_HUMAN
NCBI Summary for CHRM3
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. [provided by RefSeq, Jul 2008]
UniProt Comments for CHRM3
mAChR M3: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Defects in CHRM3 are the cause of Eagle-Barrett syndrome (EGBRS). EGBRS is a syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily.
Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q43
Cellular Component: integral to plasma membrane; plasma membrane; synapse
Molecular Function: acetylcholine binding; G-protein coupled acetylcholine receptor activity; phosphoinositide phospholipase C activity; protein binding; receptor activity
Biological Process: acetylcholine receptor signaling, muscarinic pathway; cell proliferation; G-protein coupled receptor protein signaling pathway; muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway; muscarinic acetylcholine receptor, phospholipase C activating pathway; nervous system development; protein modification process; regulation of vascular smooth muscle contraction; signal transduction; synaptic transmission, cholinergic
Disease: Abdominal Muscles, Absence Of, With Urinary Tract Abnormality And Cryptorchidism
Research Articles on CHRM3
1. Blockading CHRM3 by shRNA or treatment with darifenacin inhibited prostate cancer growth.
Precautions
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Disclaimer
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