Product Name
ABRA, Blocking Peptide
Product Synonym Names
Actin-binding Rho-activating protein; Striated muscle activator of Rho-dependent signaling; STARS; ABRA
Product Gene Name
ABRA blocking peptide
[Similar Products]
Antibody/Peptide Pairs
ABRA peptide (MBS9219436) is used for blocking the activity of ABRA antibody (MBS9208483)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8N0Z2
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Cytoplasm, myofibril, sarcomere. Cytoplasm, cytoskeleton Note: Localized to the I-band of the sarcomere and to a lesser extent to the sarcomeric structure between Z-lines.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of ABRA blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ABRA blocking peptide
Acts as an activator of serum response factor (SRF)- dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling.
NCBI/Uniprot data below describe general gene information for ABRA. It may not necessarily be applicable to this product.
NCBI Accession #
Q8N0Z2.1
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UniProt Primary Accession #
Q8N0Z2
[Other Products]
UniProt Related Accession #
Q8N0Z2[Other Products]
Molecular Weight
43,117 Da
NCBI Official Full Name
Actin-binding Rho-activating protein
NCBI Official Synonym Full Names
actin binding Rho activating protein
NCBI Official Symbol
ABRA??[Similar Products]
NCBI Official Synonym Symbols
STARS
??[Similar Products]
NCBI Protein Information
actin-binding Rho-activating protein
UniProt Protein Name
Actin-binding Rho-activating protein
UniProt Synonym Protein Names
Striated muscle activator of Rho-dependent signaling; STARS
Protein Family
Actin-binding Rho-activating protein
UniProt Gene Name
ABRA??[Similar Products]
UniProt Synonym Gene Names
STARS??[Similar Products]
UniProt Entry Name
ABRA_HUMAN
UniProt Comments for ABRA
ABRA: Acts as an activator of serum response factor (SRF)- dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling.
Protein type: Contractile; Actin-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 8q23.1
Cellular Component: actin cytoskeleton; plasma membrane; sarcomere
Molecular Function: actin binding
Biological Process: positive regulation of Rho protein signal transduction; positive regulation of transcription factor activity
Research Articles on ABRA
1. These results show that resistance exercise provides an acute stimulation of the STARS pathway that is contraction mode dependent.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
