Full Product Name
KPBB Antibody
Product Synonym Names
Phosphorylase b kinase regulatory subunit beta; Phosphorylase kinase subunit beta; PHKB
Product Gene Name
anti-KPBB antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q93100
Specificity
The antibody detects endogenous levels of total KPBB protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (lot specific)
Immunogen Description
Synthesized peptide derived from internal of human KPBB.
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-KPBB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KPBB antibody
Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation.Wuellrich-Schmoll A., Eur. J. Biochem. 238:374-380(1996).van den Berg I.E.T., Am. J. Hum. Genet. 61:539-546(1997).
Product Categories/Family for anti-KPBB antibody
Total protein Ab
Applications Tested/Suitable for anti-KPBB antibody
Western Blot (WB)
Application Notes for anti-KPBB antibody
Western blotting: 1:500~1:3000
Western Blot (WB) of anti-KPBB antibody
Western blot analysis of extracts from K562 cells, using KPBB antibody.

NCBI/Uniprot data below describe general gene information for KPBB. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000284.1
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NCBI GenBank Nucleotide #
NM_000293.2
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UniProt Primary Accession #
Q93100
[Other Products]
UniProt Secondary Accession #
Q8N4T5[Other Products]
UniProt Related Accession #
Q93100[Other Products]
Molecular Weight
123,824 Da
NCBI Official Full Name
phosphorylase b kinase regulatory subunit beta isoform a
NCBI Official Synonym Full Names
phosphorylase kinase, beta
NCBI Official Symbol
PHKB??[Similar Products]
NCBI Protein Information
phosphorylase b kinase regulatory subunit beta
UniProt Protein Name
Phosphorylase b kinase regulatory subunit beta
UniProt Gene Name
PHKB??[Similar Products]
UniProt Synonym Gene Names
Phosphorylase kinase subunit beta??[Similar Products]
UniProt Entry Name
KPBB_HUMAN
NCBI Summary for KPBB
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, encoded by this gene, which is a member of the phosphorylase b kinase regulatory subunit family. The gamma subunit also includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9B, also known as phosphorylase kinase deficiency of liver and muscle. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. Two pseudogenes have been found on chromosomes 14 and 20, respectively.[provided by RefSeq, Feb 2010]
UniProt Comments for KPBB
PHKB: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation. Defects in PHKB are the cause of glycogen storage disease type 9B (GSD9B); also known as phosphorylase kinase deficiency of liver and muscle (PKD). GSD9B is a metabolic disorder characterized by hepathomegaly, only slightly elevated transaminases and plasma lipids, clinical improvement with increasing age, and remarkably no clinical muscle involvement. Biochemical observations suggest that this mild phenotype is caused by an incomplete holoenzyme that lacks the beta subunit, but that may possess residual activity. Belongs to the phosphorylase b kinase regulatory chain family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 16q12-q13
Cellular Component: plasma membrane; phosphorylase kinase complex; cytosol
Molecular Function: calmodulin binding; phosphorylase kinase activity; protein binding; hydrolase activity, hydrolyzing O-glycosyl compounds
Biological Process: glycogen metabolic process; generation of precursor metabolites and energy; glycogen catabolic process; carbohydrate metabolic process; glucose metabolic process; pathogenesis; protein amino acid phosphorylation
Disease: Glycogen Storage Disease Ixb
Research Articles on KPBB
1. Analysis showed that the glycogen phosphorylase kinase beta-subunit (PHKB) interacted with the C-terminal region of KIAA1199 protein.
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