Product Name
Clarin 1 (CLRN1), ELISA Kit
Full Product Name
Human Clarin 1 (CLRN1) ELISA Kit
Product Gene Name
CLRN1 elisa kit
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
Request Current Manual
Samples
Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
Preparation and Storage
Store all reagents at 2-8 degree C.
Sample Preparation
We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of CLRN1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for CLRN1 purchase
MBS7231950 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Clarin 1 (CLRN1) ELISA Kit target analytes in
biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CLRN1. The ELISA analytical biochemical technique of the MBS7231950 kit is based on CLRN1 antibody-CLRN1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CLRN1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CLRN1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Product Categories/Family for CLRN1 elisa kit
Neurobiology
NCBI/Uniprot data below describe general gene information for CLRN1. It may not necessarily be applicable to this product.
NCBI Accession #
AAH74971.1
[Other Products]
UniProt Secondary Accession #
Q8N6A9; D3DNJ3; E1ACU9[Other Products]
UniProt Related Accession #
P58418[Other Products]
Molecular Weight
27,192 Da
NCBI Official Full Name
Clarin 1
NCBI Official Synonym Full Names
clarin 1
NCBI Official Symbol
CLRN1??[Similar Products]
NCBI Official Synonym Symbols
RP61; USH3; USH3A
??[Similar Products]
NCBI Protein Information
clarin-1; Usher syndrome type-3 protein
UniProt Protein Name
Clarin-1
UniProt Synonym Protein Names
Usher syndrome type-3 protein
UniProt Gene Name
CLRN1??[Similar Products]
UniProt Synonym Gene Names
USH3A??[Similar Products]
UniProt Entry Name
CLRN1_HUMAN
NCBI Summary for CLRN1
This gene encodes a protein that contains a cytosolic N-terminus, multiple helical transmembrane domains, and an endoplasmic reticulum membrane retention signal, TKGH, in the C-terminus. The encoded protein may be important in development and homeostasis of the inner ear and retina. Mutations within this gene have been associated with Usher syndrome type IIIa. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for CLRN1
USH3A: May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina. Defects in CLRN1 are the cause of Usher syndrome type 3A (USH3A). USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH3 is characterized by postlingual progressive deafness and onset of retinitis pigmentosa in the second decade of life. Defects in CLRN1 are the cause of retinitis pigmentosa type 61 (RP61). RP61 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Belongs to the clarin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 3q25
Cellular Component: microvillus; lamellipodium; integral to membrane; plasma membrane
Biological Process: sensory perception of sound; visual perception; sensory perception of light stimulus; response to stimulus; photoreceptor cell maintenance; cell motility involved in cell locomotion; actin filament organization; auditory receptor cell stereocilium organization and biogenesis; equilibrioception
Disease: Retinitis Pigmentosa; Usher Syndrome, Type Iiia; Retinitis Pigmentosa 61
Research Articles on CLRN1
1. Possible digenism could not be excluded in two families segregating genomic variations in both MYO7A and USH2A, and two families with CLRN1 and USH2A.
Precautions
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Disclaimer
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