Product Name
KIR3DS1, Polyclonal Antibody
Full Product Name
KIR3DS1 Antibody - middle region
Product Gene Name
anti-KIR3DS1 antibody
[Similar Products]
Product Synonym Gene Name
KIR-G1; NKAT10; CD158E2; NKAT-10; KIR-123FM[Similar Products]
Antibody/Peptide Pairs
KIR3DS1 peptide (MBS3231308) is used for blocking the activity of KIR3DS1 antibody (MBS3206342)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: IMFEHFFLHK EWISKDPSRL VGQIHDGVSK ANFSIGSMMR ALAGTYRCYG
3D Structure
ModBase 3D Structure for Q4KN23
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human KIR3DS1
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-KIR3DS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KIR3DS1 antibody
This is a rabbit polyclonal antibody against KIR3DS1. It was validated on Western Blot
Target Description: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Product Categories/Family for anti-KIR3DS1 antibody
Polyclonal; Various;
Applications Tested/Suitable for anti-KIR3DS1 antibody
Western Blot (WB)
Western Blot (WB) of anti-KIR3DS1 antibody
Host: Rabbit
Target Name: KIR3DS1
Sample Type: Lung Tumor lysates
Antibody Dilution: 1.0ug/ml

NCBI/Uniprot data below describe general gene information for KIR3DS1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001269100.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001282171.1
[Other Products]
UniProt Primary Accession #
Q4KN23
[Other Products]
UniProt Related Accession #
Q14943[Other Products]
NCBI Official Full Name
killer cell immunoglobulin-like receptor 3DS1 isoform 3
NCBI Official Synonym Full Names
killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1
NCBI Official Symbol
KIR3DS1??[Similar Products]
NCBI Official Synonym Symbols
KIR-G1; NKAT10; CD158E2; NKAT-10; KIR-123FM
??[Similar Products]
NCBI Protein Information
killer cell immunoglobulin-like receptor 3DS1
Protein Family
Killer cell immunoglobulin-like receptor
NCBI Summary for KIR3DS1
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
Research Articles on KIR3DS1
1. interactions between KIR3DS1 and HLA-F contribute to NK cell-mediated control of HCV.
Precautions
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Disclaimer
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