Product Name
KIR3DS1, Polyclonal Antibody
Popular Item
Full Product Name
KIR3DS1 Polyclonal Antibody
Product Gene Name
anti-KIR3DS1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q14943
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity purification
Immunogen
Recombinant protein of human KIR3DS1
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Other Notes
Small volumes of anti-KIR3DS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-KIR3DS1 antibody
Polyclonal
Applications Tested/Suitable for anti-KIR3DS1 antibody
Western Blot (WB)
Application Notes for anti-KIR3DS1 antibody
WB: 1:500 - 1:2000
Western Blot (WB) of anti-KIR3DS1 antibody
Western blot analysis of extracts of various cell lines, using KIR3DS1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 60s.

NCBI/Uniprot data below describe general gene information for KIR3DS1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001077008.1
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NCBI GenBank Nucleotide #
NM_001083539.2
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UniProt Primary Accession #
Q14943
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UniProt Related Accession #
Q14943[Other Products]
Molecular Weight
Calculated MW: 43kDa
Molecular Weight: 387 (382)
NCBI Official Full Name
killer cell immunoglobulin-like receptor 3DS1 isoform 1
NCBI Official Synonym Full Names
killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1
NCBI Official Symbol
KIR3DS1??[Similar Products]
NCBI Official Synonym Symbols
KIR-G1; NKAT10; CD158E2; NKAT-10; KIR-123FM
??[Similar Products]
NCBI Protein Information
killer cell immunoglobulin-like receptor 3DS1
UniProt Protein Name
Killer cell immunoglobulin-like receptor 3DS1
UniProt Synonym Protein Names
MHC class I NK cell receptor; Natural killer-associated transcript 10; NKAT-10
Protein Family
Killer cell immunoglobulin-like receptor
UniProt Gene Name
KIR3DS1??[Similar Products]
UniProt Synonym Gene Names
NKAT10; NKAT-10??[Similar Products]
UniProt Entry Name
KI3S1_HUMAN
NCBI Summary for KIR3DS1
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
UniProt Comments for KIR3DS1
KIR3DS1: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. Belongs to the immunoglobulin superfamily.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.4
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: MHC class I receptor activity
Biological Process: immune response; innate immune response; natural killer cell activation; signal transduction
Research Articles on KIR3DS1
1. genetic polymorphism is not related to acute myeloid leukemia in Chinese population
Precautions
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Disclaimer
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