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KIR3DS1, Blocking Peptide

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產(chǎn)品名稱: KIR3DS1, Blocking Peptide
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KIR3DS1, Blocking Peptide


KIR3DS1, Blocking Peptide  的詳細(xì)介紹
Product Name

KIR3DS1, Blocking Peptide

Full Product Name

KIR3DS1 Antibody (C-term) Blocking Peptide

Product Synonym Names
Killer cell immunoglobulin-like receptor 3DS1; MHC class I NK cell receptor; Natural killer-associated transcript 10; NKAT-10; KIR3DS1; NKAT10
Product Gene Name

KIR3DS1 blocking peptide

[Similar Products]
Product Synonym Gene Name
NKAT10[Similar Products]
Antibody/Peptide Pairs
KIR3DS1 peptide (MBS9227780) is used for blocking the activity of KIR3DS1 antibody (MBS9211115)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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OMIM
604946
3D Structure
ModBase 3D Structure for Q14943
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human KIR3DS1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Cell membrane; Single-pass type I membrane protein
Tissue Location
Expressed in NK and T-cell lines but not in B- lymphoblastoid cell lines or in a colon carcinoma cell line
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of KIR3DS1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
KIR3DS1 blocking peptide
Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.
NCBI/Uniprot data below describe general gene information for KIR3DS1. It may not necessarily be applicable to this product.
NCBI GI #
2833258
NCBI GeneID
3813
NCBI Accession #
Q14943.1 [Other Products]
UniProt Primary Accession #
Q14943 [Other Products]
UniProt Related Accession #
Q14943[Other Products]
Molecular Weight
42,902 Da
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NCBI Official Full Name
Killer cell immunoglobulin-like receptor 3DS1
NCBI Official Synonym Full Names
killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1
NCBI Official Symbol
KIR3DS1??[Similar Products]
NCBI Official Synonym Symbols
KIR-G1; NKAT10; CD158E2; NKAT-10; KIR-123FM
??[Similar Products]
NCBI Protein Information
killer cell immunoglobulin-like receptor 3DS1
UniProt Protein Name
Killer cell immunoglobulin-like receptor 3DS1
UniProt Synonym Protein Names
MHC class I NK cell receptor; Natural killer-associated transcript 10; NKAT-10
Protein Family
Killer cell immunoglobulin-like receptor
UniProt Gene Name
KIR3DS1??[Similar Products]
UniProt Synonym Gene Names
NKAT10; NKAT-10??[Similar Products]
UniProt Entry Name
KI3S1_HUMAN
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NCBI Summary for KIR3DS1
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
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UniProt Comments for KIR3DS1
KIR3DS1: Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells. Belongs to the immunoglobulin superfamily.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: plasma membrane

Biological Process: innate immune response
Research Articles on KIR3DS1
1. genetic polymorphism is not related to acute myeloid leukemia in Chinese population
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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