17-Ketosteroid; 17-KS; 3a-Hydroxy-17-Androstanone

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

200ug/ml (lot specific)

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customera??s specifications, please inquire.

Small volumes of anti-ADT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)

36,135 Da

aldo-keto reductase family 1, member C2

aldo-keto reductase family 1 member C21

Aldo-keto reductase family 1 member C21

17-alpha-HSD??[Similar Products]

AKR1C2: Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha- DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability. Defects in AKR1C2 are a cause of 46,XY sex reversal type 8 (SRXY8). A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. Belongs to the aldo/keto reductase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.1.1.357; EC 1.3.1.20; Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450

Chromosomal Location of Human Ortholog: 17q12.2

Molecular Function: 3(or 17)-alpha-hydroxysteroid dehydrogenase activity; aldehyde reductase activity; bile acid binding; carboxylic acid binding; ketosteroid monooxygenase activity; oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; phenanthrene 9,10-monooxygenase activity; steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

Biological Process: digestion; epithelial cell differentiation; G-protein coupled receptor protein signaling pathway; positive regulation of cell proliferation; positive regulation of protein kinase B signaling cascade; progesterone metabolic process; prostaglandin metabolic process; steroid metabolic process

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