Product Name
SLC25A19, Polyclonal Antibody
Full Product Name
SLC25A19 Polyclonal Antibody
Product Synonym Names
DNC; MCPHA; MUP1; THMD3; THMD4; TPC
Product Gene Name
anti-SLC25A19 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
MVGYDPKPDG RNNTKFQVAV AGSVSGLVTR ALISPFDVIK IRFQLQHERL SRSDPSAKYH GILQASRQIL QEEGPTAFWK
3D Structure
ModBase 3D Structure for Q9HC21
Purity/Purification
Affinity Purification
Immunogen
Recombinant protein of human SLC25A19
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Cellular Location
Mitochondrion inner membrane, Multi-pass membrane protein
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
Other Notes
Small volumes of anti-SLC25A19 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SLC25A19 antibody
This gene encodes a mitochondrial protein that is a member of the solute carrier family. Although this protein was initially thought to be the mitochondrial deoxynucleotide carrier involved in the uptake of deoxynucleotides into the matrix of the mitochondria, further studies have demonstrated that this protein instead functions as the mitochondrial thiamine pyrophosphate carrier, which transports thiamine pyrophosphates into mitochondria. Mutations in this gene cause microcephaly, Amish type, a metabolic disease that results in severe congenital microcephaly, severe 2-ketoglutaric aciduria, and death within the first year. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.
Product Categories/Family for anti-SLC25A19 antibody
Polyclonal Antibodies
Applications Tested/Suitable for anti-SLC25A19 antibody
Western Blot (WB)
Application Notes for anti-SLC25A19 antibody
WB: 1:1000 - 1:2000
NCBI/Uniprot data below describe general gene information for SLC25A19. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001119593.1
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NCBI GenBank Nucleotide #
NM_001126121.1
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UniProt Primary Accession #
Q9HC21
[Other Products]
UniProt Secondary Accession #
Q6V9R7; E9PF74[Other Products]
UniProt Related Accession #
Q9HC21[Other Products]
Molecular Weight
29kDa/35kDa
NCBI Official Full Name
mitochondrial thiamine pyrophosphate carrier
NCBI Official Synonym Full Names
solute carrier family 25 member 19
NCBI Official Symbol
SLC25A19??[Similar Products]
NCBI Official Synonym Symbols
DNC; TPC; MUP1; MCPHA; THMD3; THMD4
??[Similar Products]
NCBI Protein Information
mitochondrial thiamine pyrophosphate carrier
UniProt Protein Name
Mitochondrial thiamine pyrophosphate carrier
UniProt Synonym Protein Names
Mitochondrial uncoupling protein 1; Solute carrier family 25 member 19
Protein Family
Mitochondrial thiamine pyrophosphate carrier
UniProt Gene Name
SLC25A19??[Similar Products]
UniProt Synonym Gene Names
DNC; MUP1??[Similar Products]
NCBI Summary for SLC25A19
This gene encodes a mitochondrial protein that is a member of the solute carrier family. Although this protein was initially thought to be the mitochondrial deoxynucleotide carrier involved in the uptake of deoxynucleotides into the matrix of the mitochondria, further studies have demonstrated that this protein instead functions as the mitochondrial thiamine pyrophosphate carrier, which transports thiamine pyrophosphates into mitochondria. Mutations in this gene cause microcephaly, Amish type, a metabolic disease that results in severe congenital microcephaly, severe 2-ketoglutaric aciduria, and death within the first year. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for SLC25A19
Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria.
Research Articles on SLC25A19
1. Pancreatic acinar cells Mitochondrial Thiamin Pyrophosphate uptake process is adaptively regulated by the prevailing thiamin level and this regulation is exerted at the level of transcription of the SLC25A19 gene and involves transcription factor binding affinity/epigenetic mechanisms.
Precautions
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Disclaimer
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