Product Name
ARHGEF6, Polyclonal Antibody
Full Product Name
ARHGEF6 (COOL2, KIAA0006, PIXA, Rho Guanine Nucleotide Exchange Factor 6, Alpha-Pix, COOL-2, PAK-interacting Exchange Factor alpha, Rac/Cdc42 Guanine Nucleotide Exchange Factor 6)
Product Synonym Names
Anti -ARHGEF6 (COOL2, KIAA0006, PIXA, Rho Guanine Nucleotide Exchange Factor 6, Alpha-Pix, COOL-2, PAK-interacting Exchange Factor alpha, Rac/Cdc42 Guanine Nucleotide Exchange Factor 6)
Product Gene Name
anti-ARHGEF6 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
MNPEEQIVTW LISLGVLESP KKTICDPEEF LKSSLKNGVV LCKLINRLMP GSVEKFCLDP QTEADCINNI NDFLKGCATL QVEIFDPDDL YSGVNFSKVL STLLAVNKAT EDQLSERPCG RSSSLSAANT SQTNPQGAVS STVSGLQRQS KTVEMTENGS HQLIVKARFN FKQTNEDELS VCKGDIIYVT RVEEGGWWEG TLNGRTGWFP SNYVREIKSS ERPLSPKAVK GFETAPLTKN YYTVVLQNIL DTEKEYAKEL QSLLVTYLRP LQSNNNLSTV EVTSLLGNFE EVCTFQQTLC QALEECSKFP ENQHKVGGCL LSLMPHFKSM YLAYCANHPS AVNVLTQHSD ELEQFMENQG ASSPGILILT TNLSKPFMRL EKYVTLLQEL ERHMEDTHPD HQDILKAIVA FKTLMGQCQD LRKRKQLELQ ILSEPIQAWE GEDIKNLGNV IFMSQVMVQY GACEEKEERY LMLFSNVLIM LSASPRMSGF IYQGKIPIAG TVVTRLDEIE GNDCTFEITG NTVERIVVHC NNNQDFQEWL EQLNRLIRGP ASCSSLSKTS SSSCSAHSSF SSTGQPRGPL EPPQIIKPWS LSCLRPAPPL RPSAALGYKE RMSYILKESS KSPKTMKKFL HKRKTERKPS EEEYVIRKST AALEEDAQIL KVIEAYCTSA NFQQGHGSST RKDSIPQVLL PEEEKLIIEE TRSNGQTIME EKSLVDTVYA LKDEVRELKQ ENKRMKQCLE EELKSRRDLE KLVRRLLKQT DECIRGESSS KTSILP
Chromosome Location
Chromosome: X; NC_000023.10 (135747708..135863503, complement). Location: Xq26.3
3D Structure
ModBase 3D Structure for Q15052
Species Reactivity
Human, Rabbit
Specificity
Recognizes human ARHGEF6.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Immunogen
Full length human ARHGEF6, aa1-776 (NP_004831).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-ARHGEF6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ARHGEF6 antibody
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq].
Product Categories/Family for anti-ARHGEF6 antibody
Antibodies; Abs to GTPase, Rab, Ras, Rho Proteins
Applications Tested/Suitable for anti-ARHGEF6 antibody
Western Blot (WB)
Application Notes for anti-ARHGEF6 antibody
Suitable for use in Western Blot.
NCBI/Uniprot data below describe general gene information for ARHGEF6. It may not necessarily be applicable to this product.
NCBI Accession #
AAH43505.1
[Other Products]
UniProt Primary Accession #
Q15052
[Other Products]
UniProt Secondary Accession #
Q15396; Q5JQ66; Q7Z3W1; Q86XH0; A6NMW9; A8K6S7; B1AL37[Other Products]
UniProt Related Accession #
Q15052[Other Products]
Molecular Weight
87,499 Da[Similar Products]
NCBI Official Full Name
ARHGEF6 protein
NCBI Official Synonym Full Names
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
NCBI Official Symbol
ARHGEF6??[Similar Products]
NCBI Official Synonym Symbols
PIXA; COOL2; MRX46; Cool-2; alphaPIX; alpha-PIX
??[Similar Products]
NCBI Protein Information
rho guanine nucleotide exchange factor 6; PAK-interacting exchange factor alpha; PAK-interacting exchange factor, alpha; Rac/Cdc42 guanine exchange factor (GEF) 6; rac/Cdc42 guanine nucleotide exchange factor 6
UniProt Protein Name
Rho guanine nucleotide exchange factor 6
UniProt Synonym Protein Names
Alpha-Pix; COOL-2; PAK-interacting exchange factor alpha; Rac/Cdc42 guanine nucleotide exchange factor 6
Protein Family
Rho guanine nucleotide exchange factor
UniProt Gene Name
ARHGEF6??[Similar Products]
UniProt Synonym Gene Names
COOL2; KIAA0006; PIXA??[Similar Products]
UniProt Entry Name
ARHG6_HUMAN
NCBI Summary for ARHGEF6
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq, Jul 2008]
UniProt Comments for ARHGEF6
Function: Acts as a RAC1 guanine nucleotide exchange factor (GEF).
Subunit structure: Interacts with PAK kinases through the SH3 domain. Interacts with GIT1. Component of cytoplasmic complexes, which also contain PXN, GIT1 and PAK1
By similarity. Interacts with PARVB. Interacts with BIN2. Identified in a complex with BIN2 and GIT2. Ref.10 Ref.12
Subcellular location: Cell projection ? lamellipodium
By similarity.
Tissue specificity: Ubiquitous.
Involvement in disease: Mental retardation, X-linked 46 (MRX46) [MIM:300436]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6
Sequence similarities: Contains 1 CH (calponin-homology) domain.Contains 1 DH (DBL-homology) domain.Contains 1 PH domain.Contains 1 SH3 domain.
Sequence caution: The sequence BAA02796.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on ARHGEF6
1. results suggest that low doses of chlorambucil and very low doses of chronic oxidative stress together kill Cbl-resistant ovarian carcinoma cells and ARHGEF6 signaling may have an instrumental role in induction of apoptosis in Cbl(cos) cells.
Precautions
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Disclaimer
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