Product Name
ARHGEF6, Polyclonal Antibody
Full Product Name
ARHGEF6 Antibody, FITC Conjugated
Product Synonym Names
Rho guanine nucleotide exchange factor 6; Alpha-Pix; COOL-2; PAK-interacting exchange factor alpha; Rac/Cdc42 guanine nucleotide exchange factor 6; ARHGEF6; COOL2; KIAA0006; PIXA
Product Gene Name
anti-ARHGEF6 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q15052
Purity/Purification
>95%
Protein G Purified
Immunogen
Recombinant Human Rho guanine nucleotide exchange factor 6 protein (108-239AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at-20 degree C or-80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-ARHGEF6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-ARHGEF6 antibody
Signal Transduction
Applications Tested/Suitable for anti-ARHGEF6 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for ARHGEF6. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001293106.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001306177.1
[Other Products]
UniProt Primary Accession #
Q15052
[Other Products]
UniProt Secondary Accession #
Q15396; Q5JQ66; Q7Z3W1; Q86XH0; A6NMW9; A8K6S7; B1AL37[Other Products]
UniProt Related Accession #
Q15052[Other Products]
Molecular Weight
70,791 Da
NCBI Official Full Name
rho guanine nucleotide exchange factor 6 isoform 2
NCBI Official Synonym Full Names
Rac/Cdc42 guanine nucleotide exchange factor 6
NCBI Official Symbol
ARHGEF6??[Similar Products]
NCBI Official Synonym Symbols
PIXA; COOL2; MRX46; Cool-2; alphaPIX; alpha-PIX
??[Similar Products]
NCBI Protein Information
rho guanine nucleotide exchange factor 6
UniProt Protein Name
Rho guanine nucleotide exchange factor 6
UniProt Synonym Protein Names
Alpha-Pix; COOL-2; PAK-interacting exchange factor alpha; Rac/Cdc42 guanine nucleotide exchange factor 6
Protein Family
Rho guanine nucleotide exchange factor
UniProt Gene Name
ARHGEF6??[Similar Products]
UniProt Synonym Gene Names
COOL2; KIAA0006; PIXA??[Similar Products]
NCBI Summary for ARHGEF6
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific cognitive disability. [provided by RefSeq, Jul 2008]
UniProt Comments for ARHGEF6
Acts as a RAC1 guanine nucleotide exchange factor (GEF).
Research Articles on ARHGEF6
1. In this first X chromosome-wide association study of ***** patients with IBD, we identified an IBD susceptibility locus with genome-wide significance at rs2427870 on chrXq26.3, located 66 kbp upstream of CD40LG and 83.4 kbp upstream of ARHGEF6 [OR, 1.22; combined p = 3.79 x 10-15].
Precautions
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Disclaimer
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